Human UCK2 Recombinant Protein (RPPB2676)

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SKU:
RPPB2676
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
UCK2
Synonyms:
UK
Synonyms:
UCK 2
Synonyms:
Uridine-Cytidine Kinase 2
Synonyms:
Uridine Monophosphate Kinase
Source:
Escherichia Coli
Uniprot:
Q9BZX2
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Description

Product Name:Human UCK2 Recombinant Protein
Product Code:RPPB2676
Size:25µg
Species:Human
Target:UCK2
Synonyms:UK, UCK 2, Uridine-Cytidine Kinase 2, Uridine Monophosphate Kinase, Cytidine Monophosphokinase 2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The UCK2 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 2mM DTT, 100mM NaCl, 0.1mM PMSF, 1mM EDTA and 20% glycerol .
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MAGDSEQTLQ NHQQPNGGEP FLIGVSGGTA SGKSSVCAKI VQLLGQNEVD YRQKQVVILS QDSFYRVLTS EQKAKALKGQ FNFDHPDAFD NELILKTLKE ITEGKTVQIP VYDFVSHSRK EETVTVYPAD VVLFEGILAF YSQEVRDLFQ MKLFVDTDAD TRLSRRVLRD ISERGRDLEQ ILSQYITFVK PAFEEFCLPT KKYADVIIPR GADNLVAINL IVQHIQDILN GGPSKRQTNG CLNGYTPSRK RQASESSSRP HLEHHHHHH

UCK2 is a member of the uridinekinase family. UCK2 catalyzes the phosphorylation of uridine monophosphate to uridine diphosphate and cytidine monophosphate. UCK2 has a part in the production of pyrimidine nucleoside triphosphates essential for RNA and DNA synthesis. Furthermore, an allele of this gene is an important player in mediating nonhumoral immunity to Hemophilus influenzae type B.

UCK2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 269 amino acids (1-261a.a.) and having a molecular mass of 30.3kDa.UCK2 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:UCK2: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine. Belongs to the uridine kinase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.7.1.48; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 1q24.1

Cellular Component: cytosol

Molecular Function:nucleoside kinase activity; uridine kinase activity

Biological Process: pyrimidine base metabolic process; pyrimidine nucleoside salvage

NCBI Summary:This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
UniProt Code:Q9BZX2
NCBI GenInfo Identifier:20455356
NCBI Gene ID:7371
NCBI Accession:Q9BZX2.1
UniProt Secondary Accession:Q9BZX2,Q5VV91, Q7KZV3, Q92528, Q96KG5, Q9BU42,
UniProt Related Accession:Q9BZX2
Molecular Weight:29kDa
NCBI Full Name:Uridine-cytidine kinase 2
NCBI Synonym Full Names:uridine-cytidine kinase 2
NCBI Official Symbol:UCK2  
NCBI Official Synonym Symbols:UK; UMPK; TSA903  
NCBI Protein Information:uridine-cytidine kinase 2
UniProt Protein Name:Uridine-cytidine kinase 2
UniProt Synonym Protein Names:Cytidine monophosphokinase 2; Testis-specific protein TSA903; Uridine monophosphokinase 2
Protein Family:Uridine-cytidine kinase
UniProt Gene Name:UCK2  
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