Human UBXN2B Recombinant Protein (RPPB5073)

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SKU:
RPPB5073
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
UBXN2B
Synonyms:
UBX domain-containing protein 2B
Synonyms:
p37
Synonyms:
NSFL1 cofactor p37
Synonyms:
p97 cofactor p37
Source:
Escherichia Coli
Uniprot:
Q14CS0
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Description

Product Name:Human UBXN2B Recombinant Protein
Product Code:RPPB5073
Size:10µg
Species:Human
Target:UBXN2B
Synonyms:UBX domain-containing protein 2B, p37, NSFL1 cofactor p37, p97 cofactor p37, UBXN2B.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The UBXN2B solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAEGGGP EPGEQERRSS GPRPPSARDL QLALAELYED EVKCKSSKSN RPKATVFKSP RTPPQRFYSS EHEYSGLNIV RPSTGKIVNE LFKEAREHGA VPLNEATRAS GDDKSKSFTG GGYRLGSSFC KRSEYIYGEN QLQDVQILLK LWSNGFSLDD GELRPYNEPT NAQFLESVKR GEIPLELQRL VHGGQVNLDM EDHQDQEYIK PRLRFKAFSG EGQKLGSLTP EIVSTPSSPE EEDKSILNAV VLIDDSVPTT KIQIRLADGS RLIQRFNSTH RILDVRNFIV QSRPEFAALD FILVTSFPNK ELTDESLTLL EADILNTVLL QQLK

UBX Domain Protein 2B (UBXN2B) is a 331 amino acid protein which comprises one UBX domain and one SEP domain. UBXN2B is essential for ER and Golgi biogenesis and also takes a place in their maintenance during interphase, as well as their reassembly at the end of mitosis. Through interaction with VCP, UBXN2B forms a complex that has membrane fusion activity.

UBXN2B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 354 amino acids (1-331) and having a molecular mass of 39.5 kDa. UBXN2B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:UBXN2B: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Belongs to the NSFL1C family.Protein type: Adaptor/scaffold; Endoplasmic reticulumChromosomal Location of Human Ortholog: 8q12.1Cellular Component: Golgi apparatus; endoplasmic reticulum; cytosol; nucleusMolecular Function: ubiquitin binding; protein phosphatase type 1 regulator activityBiological Process: proteasomal ubiquitin-dependent protein catabolic process; regulation of catalytic activity; nuclear envelope reassembly; Golgi organization and biogenesis; autophagic vacuole formation
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q14CS0
NCBI GenInfo Identifier:121946691
NCBI Gene ID:137886
NCBI Accession:Q14CS0.1
UniProt Secondary Accession:Q14CS0,B3KWZ3
UniProt Related Accession:Q14CS0
Molecular Weight:37,077 Da
NCBI Full Name:UBX domain-containing protein 2B
NCBI Synonym Full Names:UBX domain protein 2B
NCBI Official Symbol:UBXN2B  
NCBI Official Synonym Symbols:p37  
NCBI Protein Information:UBX domain-containing protein 2B; p97 cofactor p37; NSFL1 cofactor p37
UniProt Protein Name:UBX domain-containing protein 2B
UniProt Synonym Protein Names:NSFL1 cofactor p37; p97 cofactor p37
Protein Family:UBX domain-containing protein
UniProt Gene Name:UBXN2B  
UniProt Entry Name:UBX2B_HUMAN
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