Human UBL4A Recombinant Protein (RPPB5068)

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SKU:
RPPB5068
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
UBL4A
Synonyms:
Ubiquitin-like protein 4A
Synonyms:
Ubiquitin-like protein GDX
Synonyms:
UBL4A
Synonyms:
DXS254E
Source:
Escherichia Coli
Uniprot:
P11441
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Description

Product Name:Human UBL4A Recombinant Protein
Product Code:RPPB5068
Size:20µg
Species:Human
Target:UBL4A
Synonyms:Ubiquitin-like protein 4A, Ubiquitin-like protein GDX, UBL4A, DXS254E, GDX, UBL4, G6PD, GET5, MDY2, TMA24, DX254E.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:UBL4A protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MQLTVKALQG RECSLQVPED ELVSTLKQLV SEKLNVPVRQ QRLLFKGKAL ADGKRLSDYS IGPNSKLNLV VKPLEKVLLE EGEAQRLADS PPPQVWQLIS KVLARHFSAA DASRVLEQLQ RDYERSLSRL TLDDIERLAS RFLHPEVTET MEKGFSKLEH HHHHH

Ubiquitin-Like 4A (UBL4A) contains one ubiquitin-like domain. UBL4A is a component of the BAT3 complex, which is a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. Post-translational modification by ubiquitin and ubiquitin-related proteins plays decisive roles in protein degradation and in regulation of crucial cellular processes. Due to the fact that in mammals, transcription halts during late spermiogenesis as a result of compaction of the spermatid genome, which creates a special need for robust post-transcriptional regulation.

UBL4A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (1-157 a.a.) and having a molecular mass of 18.8kDa.UBL4A is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:UBL4A: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting.
UniProt Protein Details:

Protein type:Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytosol

Molecular Function:protein binding; small conjugating protein ligase activity

Biological Process: transport; protein modification process

UniProt Code:P11441
NCBI GenInfo Identifier:136662
NCBI Gene ID:8266
NCBI Accession:P11441.1
UniProt Secondary Accession:P11441,Q5HY80,
UniProt Related Accession:P11441
Molecular Weight:157
NCBI Full Name:Ubiquitin-like protein 4A
NCBI Synonym Full Names:ubiquitin-like 4A
NCBI Official Symbol:UBL4A  
NCBI Official Synonym Symbols:GDX; G6PD; GET5; MDY2; UBL4; TMA24; DX254E; DXS254E  
NCBI Protein Information:ubiquitin-like protein 4A; ubiquitin-like 4; ubiquitin-like protein GDX
UniProt Protein Name:Ubiquitin-like protein 4A
UniProt Synonym Protein Names:Ubiquitin-like protein GDX
Protein Family:Ubiquitin-like protein
UniProt Gene Name:UBL4A  
UniProt Entry Name:UBL4A_HUMAN
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