Human UBE2Z Recombinant Protein (RPPB2394)

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SKU:
RPPB2394
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
UBE2Z
Synonyms:
HOYS7
Synonyms:
USE1
Synonyms:
Ubiquitin-conjugating enzyme E2 Z
Synonyms:
E2 ubiquitin-conjugating enzyme Z
Source:
Escherichia Coli
Uniprot:
Q9H832
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Description

Product Name:Human UBE2Z Recombinant Protein
Product Code:RPPB2394
Size:10µg
Species:Human
Target:UBE2Z
Synonyms:HOYS7, USE1, Ubiquitin-conjugating enzyme E2 Z, E2 ubiquitin-conjugating enzyme Z, Uba6-specific E2 conjugating enzyme 1, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z, UBE2Z.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The UBE2Z solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSIYKEP PPGMFVVPDT VDMTKIHALI TGPFDTPYEG GFFLFVFRCP PDYPIHPPRV KLMTTGNNTV RFNPNFYRNG KVCLSILGTW TGPAWSPAQS ISSVLISIQS LMTENPYHNE PGFEQERHPG DSKNYNECIR HETIRVAVCD MMEGKCPCPE PLRGVMEKSF LEYYDFYEVA CKDRLHLQGQ TMQDPFGEKR GHFDYQSLLM RLGLIRQKVL ERLHNENAEM DSDSSSSGTE TDLHGSLRV

Ubiquitin Conjugating Enzyme E2Z, also known as UBE2z, is a protein coding gene which is a part of the ubiquitin-conjugating enzyme family. UBE2z catalyzes the covalent attachment of ubiquitin to various proteins. UBE2z takes part in in apoptosis regulation and is also a specific substrate for UBA6, not charged with ubiquitin by UBE1.

UBE2Z Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 269 amino acids (1-246a.a) and having a molecular mass of 30.5kDa. UBE2Z is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:UBE2Z: Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ligase; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cytoplasm; nucleoplasm

Molecular Function:ATP binding; protein binding; ubiquitin protein ligase binding

Biological Process: apoptosis; protein ubiquitination during ubiquitin-dependent protein catabolic process

NCBI Summary:This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]
UniProt Code:Q9H832
NCBI GenInfo Identifier:134035344
NCBI Gene ID:65264
NCBI Accession:Q9H832.2
UniProt Secondary Accession:Q9H832,Q7L354, Q8TCM4, Q9H893, A6N8M6, A6NC60,
UniProt Related Accession:Q9H832
Molecular Weight:28,075 Da
NCBI Full Name:Ubiquitin-conjugating enzyme E2 Z
NCBI Synonym Full Names:ubiquitin conjugating enzyme E2 Z
NCBI Official Symbol:UBE2Z  
NCBI Official Synonym Symbols:USE1; HOYS7  
NCBI Protein Information:ubiquitin-conjugating enzyme E2 Z
UniProt Protein Name:Ubiquitin-conjugating enzyme E2 Z
UniProt Synonym Protein Names:E2 ubiquitin-conjugating enzyme Z; Uba6-specific E2 conjugating enzyme 1; Use1; Ubiquitin carrier protein Z; Ubiquitin-protein ligase Z
Protein Family:Protein transport protein
UniProt Gene Name:UBE2Z  
UniProt Entry Name:UBE2Z_HUMAN
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