Human UBE2D2 Recombinant Protein (RPPB2370)

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SKU:
RPPB2370
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
UBE2D2
Synonyms:
Ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)
Synonyms:
UBC4
Synonyms:
Ubiquitin carrier protein D2
Synonyms:
Ubiquitin-conjugating enzyme E2-17 kDa 2
Source:
Escherichia Coli
Uniprot:
P62837
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Description

Product Name:Human UBE2D2 Recombinant Protein
Product Code:RPPB2370
Size:20µg
Species:Human
Target:UBE2D2
Synonyms:Ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5), UBC4, Ubiquitin carrier protein D2, Ubiquitin-conjugating enzyme E2-17 kDa 2, Ubiquitin-protein ligase D2, UBCH5B, EC 6.3.2.19, E2(17)KB2, PUBC1, UBC4/5, UBC5B, UBCH4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The UBE2D2 solution (0.5mg/ml) contains 20mM MES (pH6.0), 50mM NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV PEIARIYKTD REKYNRIARE WTQKYAM 

UBE2D2 belongs to the E2 ubiquitin-conjugating enzyme family. UBE2D2 takes part in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. UBE2D2 catalyzes ubiquitination of IkB-alpha in a SCFB-TRCP and phosphorylation dependent method.

UBE2D2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 147 amino acids (1-147) and having a molecular mass of 16.7kDa. The UBE2D2 is purified by proprietary chromatographic techniques. 

UniProt Protein Function:UBE2D2: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Belongs to the ubiquitin-conjugating enzyme family.
UniProt Protein Details:

Protein type:Ubiquitin ligase; EC 6.3.2.19; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: cytosol; nucleoplasm; protein complex; ubiquitin ligase complex

Molecular Function:protein binding; ubiquitin-protein ligase activity

Biological Process: protein autoubiquitination; protein modification process; protein polyubiquitination; protein ubiquitination; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; ubiquitin-dependent protein catabolic process

NCBI Summary:Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
UniProt Code:P62837
NCBI GenInfo Identifier:51338685
NCBI Gene ID:7322
NCBI Accession:P62837.1
UniProt Secondary Accession:P62837,P51669, Q3MN78, Q96RP6, D3DQC9,
UniProt Related Accession:P62837
Molecular Weight:13,635 Da
NCBI Full Name:Ubiquitin-conjugating enzyme E2 D2
NCBI Synonym Full Names:ubiquitin conjugating enzyme E2 D2
NCBI Official Symbol:UBE2D2  
NCBI Official Synonym Symbols:UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2  
NCBI Protein Information:ubiquitin-conjugating enzyme E2 D2
UniProt Protein Name:Ubiquitin-conjugating enzyme E2 D2
UniProt Synonym Protein Names:(E3-independent) E2 ubiquitin-conjugating enzyme D2 (EC:2.3.2.24
Protein Family:Ubiquitin-conjugating enzyme
UniProt Gene Name:UBE2D2  
UniProt Entry Name:UB2D2_HUMAN
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