Human TSR2 Recombinant Protein (RPPB5033)

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SKU:
RPPB5033
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
TSR2
Synonyms:
TSR2
Synonyms:
20S RRNA Accumulation
Synonyms:
Homolog (S Cerevisiae)
Synonyms:
WGGMotif Containing 1
Source:
Escherichia Coli
Uniprot:
Q969E8
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Description

Product Name:Human TSR2 Recombinant Protein
Product Code:RPPB5033
Size:10µg
Species:Human
Target:TSR2
Synonyms:TSR2, 20S RRNA Accumulation, Homolog (S. Cerevisiae), WGGMotif Containing 1, Pre-RRNA-Processing Protein TSR2 Homolog, DT1P1A10, DBA14, WGG1,Pre-rRNA-processing protein TSR2 homolog.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:TSR2 protein solution (0.5mg/ml) containing PBS buffer(pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAGAAED ARALFRAGVC AALEAWPALQ IAVENGFGGV HSQEKAKWLGGAVEDYFMRN ADLELDEVED FLGELLTNEF DTVVEDGSLP QVSQQLQTMF HHFQRGDGAA LREMASCITQRKCKVTATAL KTARETDEDE DDVDSVEEME VTATNDGAAT DGVCPQPEPS DPDAQTIKEE DIVEDGWTIV RRK

TSR2 is part of the TSR2 family. TSR2 is involved in 20S pre-rRNAprocessing. Among the diseases which are associated with TSR2 are blepharospasm anddiamond-blackfan anemia.

TSR2 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 213 amino acids (1-190 a.a) andhaving a molecular mass of 23.2kDa.TSR2 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:TSR2: May be involved in 20S pre-rRNA processing (Potential). Belongs to the TSR2 family.Chromosomal Location of Human Ortholog: Xp11.22Cellular Component: nucleusMolecular Function: protein bindingBiological Process: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Disease: Diamond-blackfan Anemia 14 With Mandibulofacial Dysostosis
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016]
UniProt Code:Q969E8
NCBI GenInfo Identifier:24308388
NCBI Gene ID:90121
NCBI Accession:NP_477511.1
UniProt Secondary Accession:Q969E8
UniProt Related Accession:Q969E8
Molecular Weight:21 kDa
NCBI Full Name:pre-rRNA-processing protein TSR2 homolog isoform a
NCBI Synonym Full Names:TSR2 ribosome maturation factor
NCBI Official Symbol:TSR2  
NCBI Official Synonym Symbols:WGG1; DBA14; DT1P1A10  
NCBI Protein Information:pre-rRNA-processing protein TSR2 homolog
UniProt Protein Name:Pre-rRNA-processing protein TSR2 homolog
UniProt Synonym Protein Names:
Protein Family:Pre-rRNA-processing protein
UniProt Gene Name:TSR2  
UniProt Entry Name:TSR2_HUMAN
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