Human TRAPPC2 Recombinant Protein (RPPB4999)
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주문- SKU:
- RPPB4999
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- TRAPPC2
- Synonyms:
- Trafficking Protein Particle Complex 2
- Synonyms:
- Sedlin
- Synonyms:
- SEDL
- Synonyms:
- Trafficking Protein Particle Complex Subunit 2
- Source:
- Escherichia Coli
- Uniprot:
- P0DI81
Description
| Product Name: | Human TRAPPC2 Recombinant Protein |
| Product Code: | RPPB4999 |
| Size: | 10µg |
| Species: | Human |
| Target: | TRAPPC2 |
| Synonyms: | Trafficking Protein Particle Complex 2, Sedlin, SEDL, Trafficking Protein Particle Complex Subunit 2, Spondyloepiphyseal Dysplasia Late, TRAPPC2P1, HYP38334, ZNF547L, MIP2A, TRS20, SEDT, TRAPPC2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | TRAPPC2 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSGSFYF VIVGHHDNPV FEMEFLPAGK AESKDDHRHL NQFIAHAALD LVDENMWLSN NMYLKTVDKF NEWFVSAFVT AGHMRFIMLH DIRQEDGIKN FFTDVYDLYI KFSMNPFYEP NSPIRSSAFD RKVQFLGKKH LLS |
Trafficking Protein Particle Complex 2 (TRAPPC2) is assumed to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. Moreover, the TRAPPC2 protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. TRAPPC2 gene mutations are a cause of spondyloepiphyseal dysplasia tarda (SEDT).
TRAPPC2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 163 amino acids (1-140 a.a.) and having a molecular mass of 18.8kDa.TRAPPC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TRAPPC2: Prevents MBP1-mediated transcriptional repression and antagonizes MBP1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Belongs to the TRAPP small subunits family. Sedlin subfamily. Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with MBP1 and TRAPPC2L. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: Xp22 Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; endoplasmic reticulum; nucleus Molecular Function:protein binding; transcription factor binding Biological Process: ER to Golgi vesicle-mediated transport; regulation of transcription, DNA-dependent; transcription, DNA-dependent; skeletal development Disease: Spondyloepiphyseal Dysplasia Tarda, X-linked |
| NCBI Summary: | The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | P0DI81 |
| NCBI GenInfo Identifier: | 347662477 |
| NCBI Gene ID: | 6399 |
| NCBI Accession: | P0DI81.1 |
| UniProt Related Accession: | P0DI81 |
| Molecular Weight: | 16kDa |
| NCBI Full Name: | Trafficking protein particle complex subunit 2 |
| NCBI Synonym Full Names: | trafficking protein particle complex 2 |
| NCBI Official Symbol: | TRAPPC2 |
| NCBI Official Synonym Symbols: | SEDL; SEDT; MIP2A; TRS20; ZNF547L; hYP38334; TRAPPC2P1 |
| NCBI Protein Information: | trafficking protein particle complex subunit 2 |
| UniProt Protein Name: | Trafficking protein particle complex subunit 2 |
| UniProt Synonym Protein Names: | Sedlin |
| Protein Family: | Trafficking protein particle complex |
| UniProt Gene Name: | TRAPPC2 |
| UniProt Entry Name: | TPC2A_HUMAN |
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