Human TnT Recombinant Protein (RPPB5216)

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주문
SKU:
RPPB5216
Product type:
Recombinant Protein
Size:
50ug
Species:
Human
Target:
TnT
Synonyms:
Troponin T cardiac muscle
Synonyms:
TnTc
Synonyms:
Cardiac muscle troponin T
Synonyms:
cTnT
Source:
Human Cardiac Tissue
Uniprot:
P45379
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Description

Product Name:Human TnT Recombinant Protein
Product Code:RPPB5216
Size:50µg
Species:Human
Target:TnT
Synonyms:Troponin T cardiac muscle, TnTc, Cardiac muscle troponin T, cTnT, TNNT2, CMH2, CMPD2, MGC3889.
Source:Human Cardiac Tissue
Physical Appearance:Sterile Filtered colorless liquid formulation.
Formulation:Human Cardiac Troponin T in 6M Urea, 250mM NaCl, 50mM Tris-HCl, 15mM b-mercaptoethanol, 1mM EDTA, pH-7.2.
Stability:Human TnT although stable at 10°C for 7 days, should be stored below -18°C. Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.

Troponin-T is one of three subunits that form the troponin complex of the thin filaments of striated muscle, it regulates muscle contraction in response to alterations in intracellular calcium ion concentration. TnTc is expressed only in the heart and has proved to be a specific biomarker for heart disease. Mutations in TNNT2 are associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Alternative splicing results in many tissue-specific isoforms.

Human Cardiac Troponin T produced from Human Cardiac Tissue, having a molecular weight of approximately 35 kDa.The Cardiac troponin-T is purified using a combination of ion-exchange and affinity chromatography steps.

UniProt Protein Function:TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament

Molecular Function:troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding

Biological Process: atrial cardiac muscle morphogenesis; positive regulation of ATPase activity; metabolic process; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

NCBI Summary:The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq]
UniProt Code:P45379
NCBI GenInfo Identifier:48255877
NCBI Gene ID:7139
NCBI Accession:NP_000355.2
UniProt Secondary Accession:P45379,O60214, Q99596, Q99597, Q9UM96, A2TDB9, A8K3K6
UniProt Related Accession:P45379,Q15607,Q15608,Q7Z554,Q8IZA1,Q9BUF6
Molecular Weight:35,924 Da
NCBI Full Name:troponin T, cardiac muscle isoform 1
NCBI Synonym Full Names:troponin T type 2 (cardiac)
NCBI Official Symbol:TNNT2  
NCBI Official Synonym Symbols:CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6; MGC3889  
NCBI Protein Information:troponin T, cardiac muscle; OTTHUMP00000033864; OTTHUMP00000033865; OTTHUMP00000033866; OTTHUMP00000033867; OTTHUMP00000033870; OTTHUMP00000218095; troponin T2, cardiac; cardiac muscle troponin T; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant)
UniProt Protein Name:Troponin T, cardiac muscle
UniProt Synonym Protein Names:Cardiac muscle troponin T
Protein Family:Troponin
UniProt Gene Name:TNNT2  
UniProt Entry Name:TNNT2_HUMAN
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