Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-?B, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome
Product Name:
Human TNFR1/TNFRSF1A Recombinant Protein (RPES3429)
Product Code:
RPES3429
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Tumor necrosis factor receptor superfamily member 1A,Tumor necrosis factor receptor 1,TNF-R1,Tumor necrosis factor receptor type I,TNF-RI,TNFR-I,TNFAR, TNFR1
Accession:
NP_001056.1
Sequence:
Ile22-Thr 211
Fusion tag:
N-6His
Activity:
Measured by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. he ED50 for this effect, in the presence of 0.25 ng/mL of recombinant human TNF-alpha, is 5.47 ng/ml.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Tumor Necrosis Factor Receptor I is produced by our E.coli expression system and the target gene encoding Ile22-Thr211 is expressed with a 6His tag at the N-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
23.5 kDa
AP Mol Mass:
22 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_alt데이터시트Human TNFR1/TNFRSF1A Recombinant Protein Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) is a member of the tumor necrosis factor receptor superfamily. TNFRS
system_update_alt데이터시트Human TNFR1/TNFRSF1A Recombinant Protein The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the im