Human TIFA Recombinant Protein (RPPB4960)

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SKU:
RPPB4960
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
TIFA
Synonyms:
TRAF-interacting protein with FHA domain-containing protein A
Synonyms:
Putative MAPK-activating protein PM14
Synonyms:
Putative NF-kappa-B-activating protein 20
Synonyms:
TRAF2-binding protein
Source:
Escherichia Coli
Uniprot:
Q96CG3
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Description

Product Name:Human TIFA Recombinant Protein
Product Code:RPPB4960
Size:10µg
Species:Human
Target:TIFA
Synonyms:TRAF-interacting protein with FHA domain-containing protein A, Putative MAPK-activating protein PM14, Putative NF-kappa-B-activating protein 20, TRAF2-binding protein, TIFA, T2BP, T6BP, TIFAA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:TIFA protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMTSFED ADTEETVTCL QMTVYHPGQL QCGIFQSISF NREKLPSSEV VKFGRNSNIC HYTFQDKQVS RVQFSLQLFK KFNSSVLSFE IKNMSKKTNL IVDSRELGYL NKMDLPYRCM VRFGEYQFLM EKEDGESLEF FETQFILSPR SLLQENNWPP HRPIPEYGTY SLCSSQSSSP TEMDENES

TRAF-interacting protein with FHA domain-containing protein A (TIFA) is an adapter protein that mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, triggering the downstream activation of NF-kappa-B and AP-1 pathways. The TIFA protein stimulates the oligomerization and polyubiquitination of TRAF6, leading to the activation of TAK1 and IKK through a proteasome-independent mechanism.

TIFA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 208 amino acids (1-184 a.a.) and having a molecular mass of 24kDa.TIFA is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TIFA: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.Chromosomal Location of Human Ortholog: 4q25Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q96CG3
NCBI GenInfo Identifier:74751795
NCBI Gene ID:92610
NCBI Accession:Q96CG3.1
UniProt Secondary Accession:Q96CG3
UniProt Related Accession:Q96CG3
Molecular Weight:21,445 Da
NCBI Full Name:TRAF-interacting protein with FHA domain-containing protein A
NCBI Synonym Full Names:TRAF interacting protein with forkhead associated domain
NCBI Official Symbol:TIFA  
NCBI Official Synonym Symbols:T2BP; T6BP; TIFAA  
NCBI Protein Information:TRAF-interacting protein with FHA domain-containing protein A
UniProt Protein Name:TRAF-interacting protein with FHA domain-containing protein A
UniProt Synonym Protein Names:Putative MAPK-activating protein PM14; Putative NF-kappa-B-activating protein 20; TRAF2-binding protein
Protein Family:TRAF-interacting protein with FHA domain-containing protein
UniProt Gene Name:TIFA  
UniProt Entry Name:TIFA_HUMAN
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