Human THTPA Recombinant Protein (RPPB2318)

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SKU:
RPPB2318
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
THTPA
Synonyms:
MGC2652
Synonyms:
THTP
Synonyms:
THTPASE
Source:
Escherichia Coli
Uniprot:
Q9BU02
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Description

Product Name:Human THTPA Recombinant Protein
Product Code:RPPB2318
Size:25µg
Species:Human
Target:THTPA
Synonyms:MGC2652, THTP, THTPASE.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The THTPA 1mg/ml protein solution contains 20mM Tris-HCL buffer, pH-8, 1mM DTT and 10% Glycerol.
Stability:Store THTPA at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAQGLIEVER KFLPGPGTEE RLQELGGTLE YRVTFRDTYY DTPELSLMQA DHWLRRREDS GWELKCPGAA GVLGPHTEYK ELTAEPTIVA QLCKVLRADG LGAGDVAAVL GPLGLQEVAS FVTKRSAWKL VLLGADEEEP QLRVDLDTAD FGYAVGEVEA LVHEEAEVPT ALEKIHRLSS MLGVPAQETA PAKLIVYLQR FRPQDYQRLL EVNSSRERPQ ETEDPDHCLG

THTPA enzyme is part of the THTPase family. THTPA is localized to the cytoplasm and expressed at small quantities in a variety of tissues, including testis, uterus, prostate, bladder, lung and kidney. THTPA is a hydrolase that catalyzes the H2O-dependent hydrolysis of thiamine triphosphate (THTP) to thiamine diphosphate (THDP), the main form of thiamine within the cell. THTPA occurs as a monomer and is activated at an optimal pH of 8.5.

Recombinant Human THTPA produced in E.Coli is a single, non-glycosylated polypeptide chain containing 250 amino acids (1-230 a.a.) and having a molecular mass of 27.7 kDa. THTPA is fused to a 20 amino acid His-Tag at N-Terminus and purified by conventional chromatography techniques.

UniProt Protein Function:THTP: Hydrolase highly specific for thiamine triphosphate (ThTP). Belongs to the ThTPase family.Protein type: Cofactor and Vitamin Metabolism - thiamine; EC 3.6.1.28; HydrolaseChromosomal Location of Human Ortholog: 14q11.2Cellular Component: cytosolMolecular Function: hydrolase activity; magnesium ion binding; thiamin-triphosphatase activityBiological Process: dephosphorylation; thiamin and derivative metabolic process; thiamin diphosphate metabolic process; thiamin metabolic process
UniProt Protein Details:
NCBI Summary:This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
UniProt Code:Q9BU02
NCBI GenInfo Identifier:187607407
NCBI Gene ID:79178
NCBI Accession:NP_001119811.1
UniProt Secondary Accession:Q9BU02,D3DS50, G3V4J3
UniProt Related Accession:Q9BU02
Molecular Weight:12,038 Da
NCBI Full Name:thiamine-triphosphatase isoform 1
NCBI Synonym Full Names:thiamine triphosphatase
NCBI Official Symbol:THTPA  
NCBI Official Synonym Symbols:THTP; THTPASE  
NCBI Protein Information:thiamine-triphosphatase
UniProt Protein Name:Thiamine-triphosphatase
UniProt Synonym Protein Names:
Protein Family:Thiamine-triphosphatase
UniProt Gene Name:THTPA  
UniProt Entry Name:THTPA_HUMAN
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