Human TARS Recombinant Protein (RPPB2305)

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SKU:
RPPB2305
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
TARS
Synonyms:
Threonine--tRNA ligase
Synonyms:
cytoplasmic
Synonyms:
Threonyl-tRNA synthetase
Synonyms:
ThrRS
Source:
Escherichia Coli
Uniprot:
P26639
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Description

Product Name:Human TARS Recombinant Protein
Product Code:RPPB2305
Size:10µg
Species:Human
Target:TARS
Synonyms:Threonine--tRNA ligase, cytoplasmic, Threonyl-tRNA synthetase, ThrRS, TARS.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The TARS solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 20% glycerol and 150mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MFEEKASSPS GKMGGEEKPI GAGEEKQKEG GKKKNKEGSG DGGRAELNPW PEYIYTRLEM YNILKAEHDS ILAEKAEKDS KPIKVTLPDG KQVDAESWKT TPYQIACGIS QGLADNTVIA KVNNVVWDLD RPLEEDCTLE LLKFEDEEAQ AVYWHSSAHI MGEAMERVYG GCLCYGPPIE NGFYYDMYLE EGGVSSNDFS SLEALCKKII KEKQAFERLE VKKETLLAMF KYNKFKCRIL NEKVNTPTTT VYRCGPLIDL CRGPHVRHTG KIKALKIHKN SSTYWEGKAD METLQRIYGI SFPDPKMLKE WEKFQEEAKN RDHRKIGRDQ ELYFFHELSPGSCFFLPKGA YIYNALIEFI RSEYRKRGFQ EVVTPNIFNS RLWMTSGHWQ HYSENMFSFE VEKELFALKP MNCPGHCLMF DHRPRSWREL PLRLADFGVL HRNELSGALT GLTRVRRFQQ DDAHIFCAME QIEDEIKGCL DFLRTVYSVF GFSFKLNLST RPEKFLGDIE VWDQAEKQLE NSLNEFGEKW ELNSGDGAFY GPKIDIQIKD AIGRYHQCAT IQLDFQLPIR FNLTYVSHDG DDKKRPVIVH RAILGSVERM IAILTENYGG KWPFWLSPRQ VMVVPVGPTC DEYAQKVRQQ FHDAKFMADI DLDPGCTLNK KIRNAQLAQY NFILVVGEKE KISGTVNIRT RDNKVHGERT ISETIERLQQ LKEFRSKQAE EEF

Threonyl-tRNA synthetase, cytoplasmic (TARS) is a member of the class-II aminoacyl-tRNA synthetase family. The main role of TARS is in tRNA aminoacylation. The N-terminal domain of the TARS enzyme is responsible for the competition with the ribosome whereas the catalytic and the C-terminal domain are involved in binding the 2 anticodon arm-like structures in the operator.

TARS Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 743 amino acids (1-723) and having a molecular mass of 85.6kDa.TARS is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:EC 6.1.1.3; Translation; Ligase

Chromosomal Location of Human Ortholog: 5p13.2

Cellular Component: cytoplasm; cytosol; actin cytoskeleton

Molecular Function:threonine-tRNA ligase activity; protein homodimerization activity; ATP binding

Biological Process: tRNA aminoacylation for protein translation; translation; threonyl-tRNA aminoacylation; gene expression

NCBI Summary:Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
UniProt Code:P26639
NCBI GenInfo Identifier:60267755
NCBI Gene ID:6897
NCBI Accession:P26639.3
UniProt Related Accession:P26639
Molecular Weight:~ 83kDa
NCBI Full Name:Threonine--tRNA ligase 1, cytoplasmic
NCBI Synonym Full Names:threonyl-tRNA synthetase 1
NCBI Official Symbol:TARS1  
NCBI Official Synonym Symbols:TARS; TTD7; ThrRS  
NCBI Protein Information:threonine--tRNA ligase 1, cytoplasmic
UniProt Protein Name:Threonine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names:Threonyl-tRNA synthetase; ThrRS
UniProt Gene Name:TARS  
UniProt Entry Name:SYTC_HUMAN
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