Human TAGLN2 Recombinant Protein (RPPB4902)

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SKU:
RPPB4902
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
TAGLN2
Synonyms:
Transgelin-2
Synonyms:
SM22-alpha homolog
Synonyms:
TAGLN2
Synonyms:
KIAA0120
Source:
Escherichia Coli
Uniprot:
P37802
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Description

Product Name:Human TAGLN2 Recombinant Protein
Product Code:RPPB4902
Size:20µg
Species:Human
Target:TAGLN2
Synonyms:Transgelin-2, SM22-alpha homolog, TAGLN2, KIAA0120, HA1756.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The TAGLN2 solution (1 mg/ml), 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEVQQKIEKQ YDADLEQILI QWITTQCRKD VGRPQPGREN FQNWLKDGTV LCELINALYP EGQAPVKKIQ ASTMAFKQME QISQFLQAAE RYGINTTDIF QTVDLWEGKN MACVQRTLMN LGGLAVARDD GLFSGDPNWF PKKSKENPRN FSDNQLQEGK NVIGLQMGTN RGASQAGMTG YGMPRQIL

Transgelin 2 (TAGLN2) is one of the earliest markers of differentiated smooth muscle. TAGLN2 contains a calponin like repeat and a calponin-homology (CH) domain. TAGLN2 is downregulated in some transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. TAGLN2 also binds actin, causing actin fibers to gel within minutes of binding. The binding of transgelin to actin occurs at a ratio of 1:6 actin monomers.

TAGLN2 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 208 amino acids (13-199 a.a.) and having a molecular mass of 23.4kDa. The TAGLN2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:TAGLN2: a cytoskeletal protein of the calponin family. One of the earliest markers of differentiated smooth muscle. Expressed in the smooth, cardiac, and skeletal muscle cells during early embryogenesis. Becomes restricted to vascular and visceral smooth muscle cells in late fetal development and adulthood. Its expression is abolished by activated Ras. Ras-dependent and Ras-independent mechanisms can cause the down-regulation of transgelin in breast and colon cancer cells lines and tumor samples.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21-q25

Cellular Component: vesicle

Molecular Function:protein binding

Biological Process: epithelial cell differentiation

NCBI Summary:The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
UniProt Code:P37802
NCBI GenInfo Identifier:586000
NCBI Gene ID:8407
NCBI Accession:P37802.3
UniProt Secondary Accession:P37802,Q5JRQ6, Q5JRQ7, Q6FGI1, Q9BUH5, Q9H4P0, E9KL39
UniProt Related Accession:P37802
Molecular Weight:24,454 Da
NCBI Full Name:Transgelin-2
NCBI Synonym Full Names:transgelin 2
NCBI Official Symbol:TAGLN2  
NCBI Official Synonym Symbols:HA1756  
NCBI Protein Information:transgelin-2
UniProt Protein Name:Transgelin-2
UniProt Synonym Protein Names:Epididymis tissue protein Li 7e; SM22-alpha homolog
Protein Family:Transgelin
UniProt Gene Name:TAGLN2  
UniProt Entry Name:TAGL2_HUMAN
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