Human SYT11 Recombinant Protein (RPPB4891)

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SKU:
RPPB4891
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SYT11
Synonyms:
SynaptotagminXI
Synonyms:
SytXI
Synonyms:
Synaptotagmin 12
Synonyms:
KIAA0080
Source:
Escherichia Coli
Uniprot:
Q9BT88
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Description

Product Name:Human SYT11 Recombinant Protein
Product Code:RPPB4891
Size:10µg
Species:Human
Target:SYT11
Synonyms:SynaptotagminXI, SytXI, Synaptotagmin 12, KIAA0080, SYT12, Synaptotagmin-11.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SYT11 protein solution (0.25mg/ml) containing PhosphateBuffered Saline (pH7.4) and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSWSCCHQQ AEKKQKNPPY KFIHMLKGIS IYPETLSNKK KIIKVRRDKDGPGREGGRRN LLVDAAEAGL LSRDKDPRGP SSGSCIDQLP IKMDYGEELR SPITSLTPGE SKTTSPSSPEEDVMLGSLTF SVDYNFPKKA LVVTIQEAHG LPVMDDQTQGSDPYIKMTIL PDKRHRVKTR VLRKTLDPVF DETFTFYGIP YSQLQDLVLHFLVLSFDRFS RDDVIGEVMV PLAGVDPSTG KVQLTRDIIK RNIQKCISRG ELQVSLSYQP VAQRMTVVVLKARHLPKMDI TGLSGNPYVK VNVYYGRKRI AKKKTHVKKC TLNPIFNESF IYDIPTDLLPDISIEFLVID FDRTTKNEVVGRLILGAHSV TASGAEHWRE VCESPRKPVA KWHSLSEY

Synaptotagmin-11 (SYT11) protein may be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may function as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

SYT11 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 418 amino acids (37-431 a.a) andhaving a molecular mass of 47kDa.SYT11 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:SYT11: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Belongs to the synaptotagmin family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: synaptic vesicle; synaptic vesicle membrane; integral to plasma membrane; cell junction

Molecular Function:protein binding; calcium-dependent phospholipid binding; transporter activity; calcium ion binding

Biological Process: transport; negative regulation of neurotransmitter secretion

NCBI Summary:This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]
UniProt Code:Q9BT88
NCBI GenInfo Identifier:15489165
NCBI Gene ID:23208
NCBI Accession:AAH13690.1
UniProt Secondary Accession:Q9BT88,Q14998, Q5W0D4, Q68CT5, Q8IXU3, Q96SU2,
UniProt Related Accession:Q9BT88
Molecular Weight:48,297 Da
NCBI Full Name:Synaptotagmin XI
NCBI Synonym Full Names:synaptotagmin XI
NCBI Official Symbol:SYT11  
NCBI Official Synonym Symbols:SYT12; sytXI  
NCBI Protein Information:synaptotagmin-11; synaptotagmin 12
UniProt Protein Name:Synaptotagmin-11
UniProt Synonym Protein Names:Synaptotagmin XI; SytXI
Protein Family:Synaptotagmin
UniProt Gene Name:SYT11  
UniProt Entry Name:SYT11_HUMAN
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