Human SVIP Recombinant Protein (RPPB4883)

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SKU:
RPPB4883
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SVIP
Synonyms:
Small VCP/P97-Interacting Protein
Synonyms:
SVIP
Source:
Escherichia Coli
Uniprot:
Q8NHG7
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Description

Product Name:Human SVIP Recombinant Protein
Product Code:RPPB4883
Size:10µg
Species:Human
Target:SVIP
Synonyms:Small VCP/P97-Interacting Protein, SVIP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The SVIP solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGLCFPC PGESAPPTPD LEEKRAKLAE AAERRQKEAA SRGILDVQSV QEKRKKKEKI EKQIATSGPP PEGGLRWTVS
UniProt Code:Q8NHG7

Small VCP/p97-interacting protein (SVIP) is involved in various cellular processes, including membrane fusion and ubiquitin-dependent protein degradation. SVIP functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. On the other hand, SVIP overexpression increased the levels of p62 protein and enhanced starvation-activated autophagy as well as stimulated sequestration of polyubiquitinated proteins and p62 in autophagosomes.

SVIP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 100 amino acids (1-77) and having a molecular mass of 10.8 kDa.SVIP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

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