Human SULT1C2 Recombinant Protein (RPPB2294)
- SKU:
- RPPB2294
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- SULT1C2
- Synonyms:
- Sulfotransferase 1C2
- ST1C2
- Sulfotransferase 1C1
- SULT1C#1
- Source:
- Escherichia Coli
- Uniprot:
- O00338
Description
| Product Name: | Human SULT1C2 Recombinant Protein |
| Product Code: | RPPB2294 |
| Size: | 25µg |
| Species: | Human |
| Target: | SULT1C2 |
| Synonyms: | Sulfotransferase 1C2, ST1C2, Sulfotransferase 1C1, SULT1C#1, humSULTC2, SULT1C2, SULT1C1, ST1C1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SULT1C2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MALTSDLGKQ IKLKEVEGTL LQPATVDNWS QIQSFEAKPD DLLICTYPKA GTTWIQEIVD MIEQNGDVEK CQRAIIQHRH PFIEWARPPQ PSGVEKAKAM PSPRILKTHL STQLLPPSFW ENNCKFLYVA RNAKDCMVSY YHFQRMNHML PDPGTWEEYF ETFINGKVVW GSWFDHVKGW WEMKDRHQIL FLFYEDIKRD PKHEIRKVMQ FMGKKVDETV LDKIVQETSF EKMKENPMTN RSTVSKSILD QSISSFMRKG TVGDWKNHFT VAQNERFDEI YRRKMEGTSI NFCMEL |
Sulfotransferase 1C2 (SULT1C2) is a member the sulfotransferase1 superfamily. SULT1C2 catalyzes the transfer of sulfate from PAPS (3’-phosphoadenosine-5’-phosphosulfate) to phenol-containing compounds, including hormones and neurotransmitters. A short and a long isoform of SULT1C2 exist as a result of alternative splicing events. Sulfotransferase enzymes catalyze the sulfate conjugation of various hormones, neurotransmitters, drugs, and xenobiotic compounds.
SULT1C2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 316 amino acids (1-296a.a.) and having a molecular mass of 37.0kDa.SULT1C2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SULT1C1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.8.2.- Chromosomal Location of Human Ortholog: 2q12.3 Cellular Component: cytoplasm; cytosol Molecular Function:aryl sulfotransferase activity; protein binding; sulfotransferase activity Biological Process: 3'-phosphoadenosine 5'-phosphosulfate metabolic process; amine metabolic process; sulfation |
| NCBI Summary: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00338 |
| NCBI GenInfo Identifier: | 29029530 |
| NCBI Gene ID: | 6819 |
| NCBI Accession: | NP_789795 |
| UniProt Secondary Accession: | O00338,Q53SG4, B2R813, |
| UniProt Related Accession: | O00338 |
| Molecular Weight: | 35,868 Da |
| NCBI Full Name: | sulfotransferase 1C2 isoform b |
| NCBI Synonym Full Names: | sulfotransferase family 1C member 2 |
| NCBI Official Symbol: | SULT1C2 |
| NCBI Official Synonym Symbols: | ST1C1; ST1C2; SULT1C1; humSULTC2 |
| NCBI Protein Information: | sulfotransferase 1C2 |
| UniProt Protein Name: | Sulfotransferase 1C2 |
| UniProt Synonym Protein Names: | Sulfotransferase 1C1; SULT1C#1; humSULTC2 |
| Protein Family: | Sulfotransferase |
| UniProt Gene Name: | SULT1C2 |
| UniProt Entry Name: | ST1C2_HUMAN |
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