Human STK3 Recombinant Protein (RPPB2651)

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SKU:
RPPB2651
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
STK3
Synonyms:
Serine/Threonine Kinase 3
Synonyms:
Mammalian STE20-like proteinkinase 2
Synonyms:
MST-2
Synonyms:
STE20-like kinase MST2
Source:
Sf9 Insect cells
Uniprot:
Q13188
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Description

Product Name:Human STK3 Recombinant Protein
Product Code:RPPB2651
Size:10µg
Species:Human
Target:STK3
Synonyms:Serine/Threonine Kinase 3, Mammalian STE20-like proteinkinase 2, MST-2, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1,MST2/N, MST2/C, KRS1,MST2.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:STK3 protein solution (0.25mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:ADPMEQPPAP KSKLKKLSEDSLTKQPEEVF DVLEKLGEGS YGSVFKAIHK ESGQVVAIKQ VPVESDLQEI IKEISIMQQC DSPYVVKYYG SYFKNTDLWIVMEYCGAGSV SDIIRLRNKT LIEDEIATIL KSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGVAGQLTDTMAK RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITSIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW SDDFTDFVKK CLVKNPEQRA TATQLLQHPF IKNAKPVSIL RDLITEAMEI KAKRHEEQQR ELEEEEENSDEDELDHHHHH H

Serine/threonine-protein kinase 3 (), is a mammalian Ste20-relatedprotein kinases most closely related to Drosophila Hippo, which is a major regulatorof cell proliferation as well as survival in the course of development.  STK3 is a serine/threonine kinase whichfunctions early in a pheromone responsive signal transduction cascade in yeast.Furthermore, STK3 activates the human large tumor suppressor kinase Lats1. STK3also modulates stress-induced cardiac hypertrophy.

STK3 Human Recombinant produced in Sf9 Insect cell is asingle, non-glycosylated polypeptide chain containing 331 amino acids (1-322aa.a)and having a molecular mass of 37.6kDa (Migrates at 40-57kDa on SDS-PAGE underreducing conditions).STK3 is fused to a 6 amino acidHis tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:MST2: a protein kinase of the STE20 family. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Following cleavage by caspase-3, undergoes irreversible autophosphorylation. Full-length is mainly unphosphorylated in the rat thymus and cultured cells, whereas caspase-3-cleaved MST2 in apoptotic cells is highly phosphorylated.
UniProt Protein Details:

Protein type:Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Autophagy; EC 2.7.11.1; STE group; STE20 family; MST subfamily

Chromosomal Location of Human Ortholog: 8q22.2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:protein dimerization activity; protein serine/threonine kinase activity; protein serine/threonine kinase activator activity; protein binding; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: central nervous system development; positive regulation of protein binding; protein stabilization; positive regulation of apoptosis; apoptosis; positive regulation of JNK cascade; signal transduction; negative regulation of organ growth; protein amino acid phosphorylation; negative regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; neural tube formation

NCBI Summary:This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:Q13188
NCBI GenInfo Identifier:46577700
NCBI Gene ID:6788
NCBI Accession:Q13188.2
UniProt Secondary Accession:Q13188,Q15445, Q15801, Q96FM6, A8K722, B3KYA7,
UniProt Related Accession:Q13188
Molecular Weight:491
NCBI Full Name:Serine/threonine-protein kinase 3
NCBI Synonym Full Names:serine/threonine kinase 3
NCBI Official Symbol:STK3  
NCBI Official Synonym Symbols:KRS1; MST2  
NCBI Protein Information:serine/threonine-protein kinase 3; MST-2; STE20-like kinase MST2; mammalian STE20-like protein kinase 2; serine/threonine-protein kinase Krs-1; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog)
UniProt Protein Name:Serine/threonine-protein kinase 3
UniProt Synonym Protein Names:Mammalian STE20-like protein kinase 2; MST-2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1Cleaved into the following 2 chains:Serine/threonine-protein kinase 3 36kDa subunit; MST2/N; Serine/threonine-protein kinase 3 20kDa subunit; MST2/C
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:STK3  
UniProt Entry Name:STK3_HUMAN
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