Human STK17B Recombinant Protein (RPPB2655)

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SKU:
RPPB2655
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
STK17B
Synonyms:
Serine/threonine-protein kinase 17B
Synonyms:
EC 27111
Synonyms:
DAP kinase-related apoptosis-inducing protein kinase 2
Synonyms:
STK17B
Source:
Escherichia Coli
Uniprot:
O94768
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Description

Product Name:Human STK17B Recombinant Protein
Product Code:RPPB2655
Size:10µg
Species:Human
Target:STK17B
Synonyms:Serine/threonine-protein kinase 17B, EC 2.7.11.1, DAP kinase-related apoptosis-inducing protein kinase 2, STK17B, DRAK2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:STK17B protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSRRRFD CRSISGLLTT TPQIPIKMEN FNNFYILTSK ELGRGKFAVV RQCISKSTGQ EYAAKFLKKR RRGQDCRAEI LHEIAVLELA KSCPRVINLH EVYENTSEII LILEYAAGGE IFSLCLPELA EMVSENDVIR LIKQILEGVY YLHQNNIVHL DLKPQNILLS SIYPLGDIKI VDFGMSRKIG HACELREIMG TPEYLAPEIL NYDPITTATD MWNIGIIAYM LLTHTSPFVG EDNQETYLNI SQVNVDYSEE TFSSVSQLAT DFIQSLLVKN PEKRPTAEIC LSHSWLQQWD FENLFHPEET SSSSQTQDHS VRSSEDKTSK SSCNGTCGDR EDKENIPEDS SMVSKRFRFD DSLPNPHELV SDLLC

Serine/threonine kinase 17b (STK17B) is a member of the protein kinase superfamily. STK17B functions as a positive regulator of apoptosis. STK17B interacts with CHP1; this interaction stimulates CHP1 to translocate from the Golgi to the nucleus. STK17B is highly expressed in the placenta, lung, pancreas, however it has lower levels in the heart, brain, liver, skeletal muscle and kidney.

STK17B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 395 amino acids (1-372 a.a) and having a molecular mass of 44.7kDa.STK17B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DRAK2: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.Protein type: EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; DAPK familyChromosomal Location of Human Ortholog: 2q32.3Cellular Component: nucleusMolecular Function: ATP binding; protein kinase activity; protein serine/threonine kinase activityBiological Process: protein amino acid autophosphorylation; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:
UniProt Code:O94768
NCBI GenInfo Identifier:14423909
NCBI Gene ID:9262
NCBI Accession:O94768.1
UniProt Secondary Accession:O94768
UniProt Related Accession:O94768
Molecular Weight:42,344 Da
NCBI Full Name:Serine/threonine-protein kinase 17B
NCBI Synonym Full Names:serine/threonine kinase 17b
NCBI Official Symbol:STK17B  
NCBI Official Synonym Symbols:DRAK2  
NCBI Protein Information:serine/threonine-protein kinase 17B
UniProt Protein Name:Serine/threonine-protein kinase 17B
UniProt Synonym Protein Names:DAP kinase-related apoptosis-inducing protein kinase 2
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:STK17B  
UniProt Entry Name:ST17B_HUMAN
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