Human SSX1 Recombinant Protein (RPPB4835)

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SKU:
RPPB4835
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SSX1
Synonyms:
Synovial Sarcoma X Breakpoint 1
Synonyms:
Cancer/Testis Antigen 51
Synonyms:
CT51
Synonyms:
SSRC Sarcoma Synovial X-Chromosome-Related 1
Source:
Escherichia Coli
Uniprot:
Q16384
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Description

Product Name:Human SSX1 Recombinant Protein
Product Code:RPPB4835
Size:10µg
Species:Human
Target:SSX1
Synonyms:Synovial Sarcoma X Breakpoint 1, Cancer/Testis Antigen 5.1, CT5.1, SSRC Sarcoma Synovial X-Chromosome-Related 1, Cancer/Testis Antigen Family 5 Member 1, Cancer/Testis Antigen Family 5, Protein SSX1, Member 1, SSX1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SSX1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMNGDDTF AKRPRDDAKA SEKRSKAFDD IATYFSKKEW KKMKYSEKIS YVYMKRNYKA MTKLGFKVTL PPFMCNKQAT DFQGNDFDND HNRRIQVEHP QMTFGRLHRI IPKIMPKKPA EDENDSKGVS EASGPQNDGK QLHPPGKANI SEKINKRSGP KRGKHAWTHR LRERKQLVIY EEISDPEEDD E

Synovial Sarcoma, X Breakpoint 1 (SSX1) is a member of a family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. SSX proteins are localized to the nucleus and expressed in testis and some types of cancers and, hence, they are classified as C/T (cancer/testis) antigens. These proteins may serve as transcriptional repressors. SSX1 genes are involved in the t (X;18) translocation typically found in all synovial sarcomas. This translocation leads to the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. These hybrid proteins are most likely responsible for transforming activity.

SSX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (1-188 a.a) and having a molecular mass of 24.3kDa.SSX1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SSX1: Could act as a modulator of transcription. A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Belongs to the SSX family.Protein type: Oncoprotein; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xp11.23Molecular Function: protein binding; transcription corepressor activityDisease: Sarcoma, Synovial
UniProt Protein Details:
NCBI Summary:The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]
UniProt Code:Q16384
NCBI GenInfo Identifier:3915027
NCBI Gene ID:6756
NCBI Accession:Q16384.2
UniProt Secondary Accession:Q16384,Q08AJ2, Q5JQ64, A3KN76
UniProt Related Accession:Q16384
Molecular Weight:21,931 Da
NCBI Full Name:Protein SSX1
NCBI Synonym Full Names:SSX family member 1
NCBI Official Symbol:SSX1  
NCBI Official Synonym Symbols:SSRC; CT5.1  
NCBI Protein Information:protein SSX1
UniProt Protein Name:Protein SSX1
UniProt Synonym Protein Names:Cancer/testis antigen 5.1; CT5.1; Synovial sarcoma, X breakpoint 1
Protein Family:Protein
UniProt Gene Name:SSX1  
UniProt Entry Name:SSX1_HUMAN
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