Human SSR4 Recombinant Protein (RPPB4833)

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SKU:
RPPB4833
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SSR4
Synonyms:
TRAPD
Synonyms:
Translocon-associated protein subunit delta
Synonyms:
TRAP-delta
Synonyms:
Signal sequence receptor subunit delta SSR-delta
Source:
Escherichia Coli
Uniprot:
P51571
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Description

Product Name:Human SSR4 Recombinant Protein
Product Code:RPPB4833
Size:20µg
Species:Human
Target:SSR4
Synonyms:TRAPD, Translocon-associated protein subunit delta, TRAP-delta, Signal sequence receptor subunit delta SSR-delta.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SSR4 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEACLEPQ ITPSYYTTSD AVISTETVFI VEISLTCKNR VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG TYEVRFFDEE SYSLLRKAQR NNEDISIIPP LFTVSVDHRG TWNG

SSR4 is a member of the TRAP-delta family. SSR4 is the delta subunit of the translocon-associated protein complex that participates in translocating proteins through the endoplasmic reticulum membrane. SSR4 positioned in the Xq28 region and organized in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene. Both genes are motivated by a CpG-embedded bidirectional promoter.

SSR4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 144 amino acids (24-144 a.a.) and having a molecular mass of 16.1kDa.SSR4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SSR4: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Belongs to the TRAP-delta family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Disease: Congenital Disorder Of Glycosylation, Type Iy

NCBI Summary:This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]
UniProt Code:P51571
NCBI GenInfo Identifier:1711550
NCBI Gene ID:6748
NCBI Accession:P51571.1
UniProt Secondary Accession:P51571,Q53XY1, A8K378,
UniProt Related Accession:P51571
Molecular Weight:18,999 Da
NCBI Full Name:Translocon-associated protein subunit delta
NCBI Synonym Full Names:signal sequence receptor subunit 4
NCBI Official Symbol:SSR4  
NCBI Official Synonym Symbols:CDG1Y; TRAPD  
NCBI Protein Information:translocon-associated protein subunit delta
UniProt Protein Name:Translocon-associated protein subunit delta
UniProt Synonym Protein Names:Signal sequence receptor subunit delta; SSR-delta
Protein Family:SWI/SNF and RSC complexes
UniProt Gene Name:SSR4  
UniProt Entry Name:SSRD_HUMAN
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