Human SSR2 Recombinant Protein (RPPB4832)

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SKU:
RPPB4832
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SSR2
Synonyms:
HSD25
Synonyms:
TLAP
Synonyms:
TRAP-BETA
Synonyms:
TRAPB
Source:
Escherichia Coli
Uniprot:
P43308
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Description

Product Name:Human SSR2 Recombinant Protein
Product Code:RPPB4832
Size:20µg
Species:Human
Target:SSR2
Synonyms:HSD25, TLAP, TRAP-BETA, TRAPB, Translocon-associated protein subunit beta, Signal sequence receptor subunit beta, SSR-beta.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SSR2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEEGARLL ASKSLLNRYA VEGRDLTLQY NIYNVGSSAA LDVELSDDSF PPEDFGIVSG MLNVKWDRIA PASNVSHTVV LRPLKAGYFN FTSATITYLA QEDGPVVIGS TSAPGQGGIL AQREFDRRFS PHFLD

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum membrane receptor related with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. Diseases correlated with SSR2 include calcaneonavicular coalition, and osteosarcoma, and among its related super-pathways are Viral mRNA Translation and Generic Transcription Pathway.

SSR2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (18-149a.a) and having a molecular mass of 16.8kDa. SSR2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SSR2: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Belongs to the TRAP-beta family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 1q21-q23Cellular Component: endoplasmic reticulumBiological Process: cotranslational protein targeting to membrane
UniProt Protein Details:
NCBI Summary:The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]
UniProt Code:P43308
NCBI GenInfo Identifier:1174451
NCBI Gene ID:6746
NCBI Accession:P43308.1
UniProt Secondary Accession:P43308,Q53HI0, Q5VY95, Q5VY96, Q6IB31, Q9BWE4, B2R9K9 D3DVA7
UniProt Related Accession:P43308
Molecular Weight:20,135 Da
NCBI Full Name:Translocon-associated protein subunit beta
NCBI Synonym Full Names:signal sequence receptor subunit 2
NCBI Official Symbol:SSR2  
NCBI Official Synonym Symbols:TLAP; HSD25; TRAPB; TRAP-BETA  
NCBI Protein Information:translocon-associated protein subunit beta
UniProt Protein Name:Translocon-associated protein subunit beta
UniProt Synonym Protein Names:Signal sequence receptor subunit beta; SSR-beta
Protein Family:SWI/SNF and RSC complexes
UniProt Gene Name:SSR2  
UniProt Entry Name:SSRB_HUMAN
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