VPS10 domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a single-pass type I membrane protein which belongs to the SORCS family and SORCS1 subfamily. SORCS1 contains five BNR repeats and one PKD domain. SorCS1 is a member of the Vps10p-domain receptor family comprised of Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common characteristic of these receptors is an N-terminal Vps10p domain, which either represents the only module of the luminal/extracellular moiety or is combined with additional domains. Family members play roles in protein transport and signal transduction. The individual receptors bind and internalize a variety of ligands, such as neuropeptides and trophic factors, and Sortilin and SorLA mediate trans-Golgi network-to-endosome sorting. Their prominent neuronal expression, several of the identified ligands, and results support the notion that members of this receptor family have important functions in neurogenesis, plasticity-related processes, and functional maintenance of the nervous system. Sortilin and SorLA mediate intracellular protein trafficking and sorting. SorCS1 binds platelet-derived growth factor-BB (PDGF-BB) and is expressed in isoforms differing only in their cytoplasmic domains. SorCS1 binds platelet-derived growth factor, a growth factor crucial for pericyte recruitment to the microvasculature, and may thus have a role in expanding or maintaining the islet vasculature.
Product Name:
Human SorCS1 Recombinant Protein (RPES4523)
Product Code:
RPES4523
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
hSorCS,RP11-446H13.1
Accession:
Q8WY21-1
Sequence:
Ser 111-Ser 1099
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human SORCS1 (Q8WY21-1) extracellular domain (Ser 111-Ser 1099) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus
Purity:
> 92 % as determined by reducing SDS-PAGE.
Mol Mass:
113 kDa
AP Mol Mass:
130 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
