Human SNUPN Recombinant Protein (RPPB4765)

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SKU:
RPPB4765
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SNUPN
Synonyms:
KPNBL
Synonyms:
RNUT1
Synonyms:
Snurportin1
Synonyms:
SPN1
Source:
Escherichia Coli
Uniprot:
O95149
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Description

Product Name:Human SNUPN Recombinant Protein
Product Code:RPPB4765
Size:20µg
Species:Human
Target:SNUPN
Synonyms:KPNBL, RNUT1, Snurportin1, SPN1, RNA U transporter 1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:SNUPN Human solution containing 20mM Tris pH-8, 2mM DTT, 0.1M NaCl, & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL QKSKRLDYVN HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN QLMLSEWLID VPSDLGQEWI VVVCPVGKRA LIVASRGSTS AYTKSGYCVN RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN QTYYVLDVMC WRGHPFYDCQ TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE SLCDVLSMDF PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS PDHPGCLMEN

SNUPN is a nuclear import adaptor protein which is part of the Snurportin family. SNUPN is Localized to the cytoplasm and nucleus and contains an N-terminal IBB domain and a trimethylguanosine (m3G)-cap binding domain. SNUPN binds specifically the terminal 2,2,7-m3G-cap at the 5'' end of U snRNPs and is involved in transport of U snRNPs into the nucleus through an association with Importin Beta.

SNUPN Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 380 amino acids (1-360 a.a.) and having a molecular mass of 43.3 kDa. The SNUPN is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:RNUT1: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family.
UniProt Protein Details:

Protein type:RNA-binding; Nuclear import

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: cytosol; nuclear pore

Molecular Function:RNA cap binding

Biological Process: nuclear import; spliceosomal snRNP biogenesis

NCBI Summary:The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O95149
NCBI GenInfo Identifier:74735576
NCBI Gene ID:10073
NCBI Accession:O95149.1
UniProt Secondary Accession:O95149,A6NE34, A8K0B0, D3DW76,
UniProt Related Accession:O95149
Molecular Weight:41,143 Da
NCBI Full Name:Snurportin-1
NCBI Synonym Full Names:snurportin 1
NCBI Official Symbol:SNUPN  
NCBI Official Synonym Symbols:KPNBL; RNUT1; Snurportin1  
NCBI Protein Information:snurportin-1
UniProt Protein Name:Snurportin-1
UniProt Synonym Protein Names:RNA U transporter 1
UniProt Gene Name:SNUPN  
UniProt Entry Name:SPN1_HUMAN
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