Human SNRPC Recombinant Protein (RPPB4753)

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SKU:
RPPB4753
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SNRPC
Synonyms:
U1 small nuclear ribonucleoprotein C
Synonyms:
U1 snRNP C
Synonyms:
U1-C
Synonyms:
U1C
Source:
Sf9 Insect cells
Uniprot:
P09234
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Description

Product Name:Human SNRPC Recombinant Protein
Product Code:RPPB4753
Size:10µg
Species:Human
Target:SNRPC
Synonyms:U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C, U1C, SNRPC, Yhc1.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:SNRPC is supplied in 20mM HEPES buffer pH-7.5, 0.01mM EDTA and 0.02% SDS.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.

SNRPC is a member of the U1 small nuclear ribonucleoprotein C family. The SNRPC protein component of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. SNRPC participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are tackled by autoantibodies frequently produced by patients with connective tissue diseases.

SNRPC Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 25,000 Dalton.SNRPC is expressed with a -6x His tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:snRNP C: Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 small nuclear ribonucleoprotein C family.
UniProt Protein Details:

Protein type:RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: Cajal body; nucleoplasm; snRNP U1

Molecular Function:pre-mRNA 5'-splice site binding; protein binding; protein homodimerization activity; single-stranded RNA binding; U1 snRNA binding; zinc ion binding

Biological Process: nuclear mRNA 5'-splice site recognition; nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis

NCBI Summary:This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009]
UniProt Code:P09234
NCBI GenInfo Identifier:134093
NCBI Gene ID:6631
NCBI Accession:P09234.1
UniProt Secondary Accession:P09234,Q5TAL3,
UniProt Related Accession:P09234
Molecular Weight:17,394 Da
NCBI Full Name:U1 small nuclear ribonucleoprotein C
NCBI Synonym Full Names:small nuclear ribonucleoprotein polypeptide C
NCBI Official Symbol:SNRPC  
NCBI Official Synonym Symbols:U1C; Yhc1  
NCBI Protein Information:U1 small nuclear ribonucleoprotein C
UniProt Protein Name:U1 small nuclear ribonucleoprotein C
UniProt Gene Name:SNRPC  
UniProt Entry Name:RU1C_HUMAN
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