Human SIRPG Recombinant Protein (RPPB4689)

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SKU:
RPPB4689
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SIRPG
Synonyms:
signal-regulatory protein gamma isoform 1 precursor
Synonyms:
bA77C31
Synonyms:
CD172g
Synonyms:
SIRP-B2
Source:
Escherichia Coli
Uniprot:
Q9P1W8
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Description

Product Name:Human SIRPG Recombinant Protein
Product Code:RPPB4689
Size:20µg
Species:Human
Target:SIRPG
Synonyms:signal-regulatory protein gamma isoform 1 precursor, bA77C3.1, CD172g, SIRP-B2, SIRPB2, SIRPgamma, Signal-Regulatory Protein Gamma, SIRPG, SIRP-b2, SIRP-beta-2, CD_antigen: CD172g, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-gamma.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SIRPG protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEEELQMI QPEKLLLVTV GKTATLHCTV TSLLPVGPVL WFRGVGPGRE LIYNQKEGHF PRVTTVSDLT KRNNMDFSIR ISSITPADVG TYYCVKFRKG SPENVEFKSG PGTEMALGAK PSAPVVLGPA ARTTPEHTVS FTCESHGFSP RDITLKWFKN GNELSDFQTN VDPTGQSVAY SIRSTARVVL DPWDVRSQVI CEVAHVTLQG DPLRGTANLS EAIRVPPTLE VTQQPMRVGN QVNVTCQVRK FYPQSLQLTW SENGNVCQRE TASTLTENKD GTYNWTSWFL VNISDQRDDV VLTCQVKHDG QLAVSKRLAL EVTVHQKDQS SDATP

Signal-Regulatory Protein Gamma (SIRPG) belongs to the signal-regulatory protein (SIRP) family whose members are receptor-type transmembrane glycoproteins which negatively regulate the receptor tyrosine kinase-coupled signaling processes. SIRPG is also a part of the immunoglobulin superfamily.

SIRPG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 355 amino acids (29-360 a.a.) and having a molecular mass of 39.1kDa.SIRPG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
NCBI Summary:The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q9P1W8
NCBI GenInfo Identifier:124053651
NCBI Gene ID:55423
NCBI Accession:Q9P1W8.3
UniProt Secondary Accession:Q9P1W8,Q5D051, Q5JV25, Q5MKL4, Q8WWA5, Q9NQK8, B1AKP6
UniProt Related Accession:Q9P1W8
Molecular Weight:29,967 Da
NCBI Full Name:Signal-regulatory protein gamma
NCBI Synonym Full Names:signal regulatory protein gamma
NCBI Official Symbol:SIRPG  
NCBI Official Synonym Symbols:CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma  
NCBI Protein Information:signal-regulatory protein gamma
UniProt Protein Name:Signal-regulatory protein gamma
UniProt Synonym Protein Names:CD172 antigen-like family member B; Signal-regulatory protein beta-2; SIRP-b2; SIRP-beta-2; CD_antigen: CD172g
Protein Family:Signal-regulatory protein
UniProt Gene Name:SIRPG  
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