Human SH3BGRL3 Recombinant Protein (RPPB4674)

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SKU:
RPPB4674
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SH3BGRL3
Synonyms:
SH3 Domain Binding Glutamic Acid-Rich Protein Like 3
Synonyms:
SH3BGRL3-Like Protein
Synonyms:
SH3 Domain-Binding Protein 1
Synonyms:
SH3BP-1
Source:
Escherichia Coli
Uniprot:
Q9H299
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Description

Product Name:Human SH3BGRL3 Recombinant Protein
Product Code:RPPB4674
Size:20µg
Species:Human
Target:SH3BGRL3
Synonyms:SH3 Domain Binding Glutamic Acid-Rich Protein Like 3, SH3BGRL3-Like Protein, SH3 Domain-Binding Protein 1, SH3BP-1, TNF Inhibitory Protein, TIP-B1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SH3BGRL3 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSGLRVY STSVTGSREI KSQQSEVTRI LDGKRIQYQL VDISQDNALR DEMRALAGNP KATPPQIVNG DQYCGDYELF VEAVEQNTLQ EFLKLA

SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) which is located on chromosome 1p34.3-35, encodes for a small 93 amino acids protein. SH3BGRL3 is the newest member of thioredoxin super family, whose posttranslational altered form was recognized as TNF-alpha inhibitory protein. SH3BGRL3 may act as a regulator in all-trans retinoic acid-induced pathway and also as a modulator of glutaredoxin biological activity.

SH3BGRL3 Human Recombinant produced in E. coli is a single polypeptide chain containing 116 amino acids (1-93) and having a molecular mass of 12.8 kDa.SH3BGRL3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SH3BGRL3: Could act as a modulator of glutaredoxin biological activity. Belongs to the SH3BGR family.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 1p36.11Cellular Component: lamellipodiumMolecular Function: GTPase activator activity; semaphorin receptor bindingBiological Process: positive regulation of GTPase activity; regulation of actin cytoskeleton organization and biogenesis; regulation of actin filament depolymerization; regulation of blood vessel endothelial cell migration
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9H299
NCBI GenInfo Identifier:24638222
NCBI Gene ID:83442
NCBI Accession:Q9H299.1
UniProt Secondary Accession:Q9H299,Q5T122
UniProt Related Accession:Q9H299
Molecular Weight:10,438 Da
NCBI Full Name:SH3 domain-binding glutamic acid-rich-like protein 3
NCBI Synonym Full Names:SH3 domain binding glutamate rich protein like 3
NCBI Official Symbol:SH3BGRL3  
NCBI Official Synonym Symbols:TIP-B1; SH3BP-1; HEL-S-297  
NCBI Protein Information:SH3 domain-binding glutamic acid-rich-like protein 3
UniProt Protein Name:SH3 domain-binding glutamic acid-rich-like protein 3
UniProt Synonym Protein Names:SH3 domain-binding protein 1; SH3BP-1
Protein Family:SH3 domain-binding glutamic acid-rich-like protein
UniProt Gene Name:SH3BGRL3  
UniProt Entry Name:SH3L3_HUMAN
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