Human SFRP4 Recombinant Protein (RPPB4656)

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SKU:
RPPB4656
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
SFRP4
Synonyms:
Secreted Frizzled Related Protein 4
Synonyms:
SecretedFrizzled-Related Protein 4
Synonyms:
Frizzled Protein
Synonyms:
Human Endometrium
Source:
Sf9 Insect cells
Uniprot:
Q6FHJ7
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Description

Product Name:Human SFRP4 Recombinant Protein
Product Code:RPPB4656
Size:5µg
Species:Human
Target:SFRP4
Synonyms:Secreted Frizzled Related Protein 4, SecretedFrizzled-Related Protein 4, Frizzled Protein, Human Endometrium, SFRP-4, FRPHESecreted Frizzled-Related Protein 4; Secreted Frizzled-Related Protein 4,FRP-4, PYL, SFRP4, FRPHE.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SFRP4 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPVRGAPCE AVRIPMCRHMPWNITRMPNH LHHSTQENAI LAIEQYEELV DVNCSAVLRF FLCAMYAPIC TLEFLHDPIK PCKSVCQRARDDCEPLMKMY NHSWPESLAC DELPVYDRGV CISPEAIVTD LPEDVKWIDI TPDMMVQERP LDVDCKRLSPDRCKCKKVKP TLATYLSKNY SYVIHAKIKA VQRSGCNEVT TVVDVKEIFK SSSPIPRTQV PLITNSSCQCPHILPHQDVL IMCYEWRSRM MLLENCLVEK WRDQLSKRSI QWEERLQEQR RTVQDKKKTA GRTSRSNPPKPKGKPPAPKP ASPKKNIKTR SAQKRTNPKR VHHHHHH

Secreted frizzled-related protein 4 (SFRP4) belongs to the SFRP family which contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs serve as soluble modulators of Wnt signaling. SFRP4 may serve as a regulator of adult uterine morphology and function. SFRP4 increases apoptosis during ovulation possibly via modulation of FZ1/FZ4/WNT4 signaling. SFRP4 also has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. SFRP4 is expressed in proliferative endometrium and several types of ovarian, endometrial and Brest tumors. SFRP4 is expressed in mesenchymal cells and in cardiomyocytes. SFRP4 expression in ventricular myocardium correlates with apoptosis related gene expression. SFRP4 is up-regulated in failing myocardium.

SFRP4 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 337 amino acids (19-346 a.a.) andhaving a molecular mass of 38.9kDa (Molecular size on SDS-PAGE will appear atapproximately 40-57kDa). SFRP4 is expressed with a 9 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:SFRP4: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Belongs to the secreted frizzled-related protein (sFRP) family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: cell surface; cytoplasm; extracellular space; integral to membrane; nucleus

Molecular Function:G-protein coupled receptor activity; protein binding; Wnt receptor activity; Wnt-protein binding

Biological Process: negative regulation of cell proliferation; negative regulation of transcription factor activity; phosphate ion homeostasis; positive regulation of apoptosis; positive regulation of epidermal cell differentiation; positive regulation of receptor internalization

NCBI Summary:Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
UniProt Code:Q6FHJ7
NCBI GenInfo Identifier:61216780
NCBI Gene ID:6424
NCBI Accession:Q6FHJ7.2
UniProt Secondary Accession:Q6FHJ7,O14877, Q05BG7, Q1ZYW2, Q4G124, Q6FHM0, Q6PD64 B4DYC1,
UniProt Related Accession:Q6FHJ7
Molecular Weight:39,827 Da
NCBI Full Name:Secreted frizzled-related protein 4
NCBI Synonym Full Names:secreted frizzled related protein 4
NCBI Official Symbol:SFRP4  
NCBI Official Synonym Symbols:PYL; FRP-4; FRPHE; sFRP-4  
NCBI Protein Information:secreted frizzled-related protein 4
UniProt Protein Name:Secreted frizzled-related protein 4
UniProt Synonym Protein Names:Frizzled protein, human endometrium; FrpHE
Protein Family:Secreted frizzled-related protein
UniProt Gene Name:SFRP4  
UniProt Entry Name:SFRP4_HUMAN
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