Human SENP8 Recombinant Protein (RPPB2266)

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SKU:
RPPB2266
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SENP8
Synonyms:
SUMO/sentrin specific peptidase family member 8
Synonyms:
DEN1
Synonyms:
NEDP1
Synonyms:
Protease cysteine 2 (NEDD8 specific)
Source:
Escherichia Coli
Uniprot:
Q96LD8
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Description

Product Name:Human SENP8 Recombinant Protein
Product Code:RPPB2266
Size:20µg
Species:Human
Target:SENP8
Synonyms:SUMO/sentrin specific peptidase family member 8, DEN1, NEDP1, Protease cysteine 2 (NEDD8 specific), PRSC2, NEDD8-specific protease 1, HsT17512, Deneddylase-1, NEDD8 specific-protease cysteine 2, Sentrin/SUMO-specific protease SENP8.
Source:Escherichia Coli
Physical Appearance:SENP8 is supplied as a sterile filtered clear solution.
Formulation:SENP8 protein 1mg/ml is supplied in 20mM Tris-HCL, pH-8, 0.1M NaCl, 1mM DTT and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MDPVVLSYMD SLLRQSDVSL LDPPSWLNDH IIGFAFEYFA NSQFHDCSDH VSFISPEVTQ FIKCTSNPAE IAMFLEPLDL PNKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS HSRSNSVHAK QVAEKLEAFL GRKGDKLAFV EEKAPAQQNS YDCGMYVICN TEALCQNFFR QQTESLLQLL TPAYITKKRG EWKDLITTLA KK

SENP8 is a cysteine protease which belongs to the sentrin-specific protease family. SENP8 takes part in processing and deconjugation of the ubiquitin-like protein labeled, neural precursor cell expressed developmentally downregulated 8(NEDD8).

SENP8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (1-212) and having a molecular mass of 26.3 kDa.The SENP8 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:SENP8: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Belongs to the peptidase C48 family.
UniProt Protein Details:

Protein type:EC 3.4.22.68; Protease

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: cytosol; nucleus

Molecular Function:endopeptidase activity; NEDD8-specific protease activity; SUMO-specific protease activity

Biological Process: protein desumoylation; protein deubiquitination

NCBI Summary:This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
UniProt Code:Q96LD8
NCBI GenInfo Identifier:26006881
NCBI Gene ID:123228
NCBI Accession:Q96LD8.1
UniProt Secondary Accession:Q96LD8,Q96QA4,
UniProt Related Accession:Q96LD8
Molecular Weight:24kDa
NCBI Full Name:Sentrin-specific protease 8
NCBI Synonym Full Names:SUMO/sentrin peptidase family member, NEDD8 specific
NCBI Official Symbol:SENP8  
NCBI Official Synonym Symbols:DEN1; NEDP1; PRSC2  
NCBI Protein Information:sentrin-specific protease 8
UniProt Protein Name:Sentrin-specific protease 8
UniProt Synonym Protein Names:Deneddylase-1; NEDD8-specific protease 1; Protease, cysteine 2; Sentrin/SUMO-specific protease SENP8
Protein Family:Sentrin-specific protease
UniProt Gene Name:SENP8  
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