Human REXO2 Recombinant Protein (RPPB2244)

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SKU:
RPPB2244
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
REXO2
Synonyms:
REX2
Synonyms:
RNA exonuclease 2 homolog (S cerevisiae)
Synonyms:
CGI-114
Synonyms:
RFN
Source:
Escherichia Coli
Uniprot:
Q9Y3B8
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Description

Product Name:Human REXO2 Recombinant Protein
Product Code:RPPB2244
Size:20µg
Species:Human
Target:REXO2
Synonyms:REX2, RNA exonuclease 2 homolog (S. cerevisiae), CGI-114, RFN, SFN, Oligoribonuclease, mitochondrial, RNA exonuclease 2 homolog, Small fragment nuclease,REXO2, SMFN.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The REXO2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSVREGGAA MAAGESMAQR MVWVDLEMTG LDIEKDQIIE MACLITDSDL NILAEGPNLI IKQPDELLDS MSDWCKEHHG KSGLTKAVKE STITLQQAEY EFLSFVRQQT PPGLCPLAGN SVHEDKKFLD KYMPQFMKHL HYRIIDVSTV KELCRRWYPE EYEFAPKKAA SHRALDDISE SIKELQFYRN NIFKKKIDEK KRKIIENGEN EKTVS

EXO2 is a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. RNA Exonuclease 2 (REXO2) takes part in DNA repair, replication, and recombination, and in RNA processing and degradation. EXO2 is involved in resistance of human cells to UV-C-induced cell death via its part in the DNA repair process.

REXO2 Human Recombinant produced in E. coli is a single polypeptide chain containing 235 amino acids (26-237) and having a molecular mass of 26.8kDa. REXO2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:REXO2: a 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily
UniProt Protein Details:

Protein type:EC 3.1.-.-; Hydrolase

Chromosomal Location of Human Ortholog: 11q23.2

Cellular Component: focal adhesion; mitochondrion; nucleolus; nucleus

Molecular Function:3'-5' exonuclease activity; 3'-5'-exoribonuclease activity

Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleotide metabolic process

NCBI Summary:This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
UniProt Code:Q9Y3B8
NCBI GenInfo Identifier:116242694
NCBI Gene ID:25996
NCBI Accession:Q9Y3B8.3
UniProt Secondary Accession:Q9Y3B8,Q32Q18, Q53FT1, Q6FIC6, Q9UFY7, B2R532,
UniProt Related Accession:Q9Y3B8
Molecular Weight:23,754 Da
NCBI Full Name:Oligoribonuclease, mitochondrial
NCBI Synonym Full Names:RNA exonuclease 2
NCBI Official Symbol:REXO2  
NCBI Official Synonym Symbols:RFN; SFN; REX2; CGI-114  
NCBI Protein Information:oligoribonuclease, mitochondrial
UniProt Protein Name:Oligoribonuclease, mitochondrial
UniProt Synonym Protein Names:RNA exonuclease 2 homolog; Small fragment nuclease
UniProt Gene Name:REXO2  
UniProt Entry Name:ORN_HUMAN
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