Human REXO1 Recombinant Protein (RPPB2243)

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SKU:
RPPB2243
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
REXO1
Synonyms:
RNA exonuclease 1 homolog
Synonyms:
Elongin-A-binding protein 1
Synonyms:
EloA-BP1
Synonyms:
Transcription elongation factor B polypeptide 3-binding protein 1
Source:
Escherichia Coli
Uniprot:
Q8N1G1
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Description

Product Name:Human REXO1 Recombinant Protein
Product Code:RPPB2243
Size:20µg
Species:Human
Target:REXO1
Synonyms:RNA exonuclease 1 homolog, Elongin-A-binding protein 1, EloA-BP1, Transcription elongation factor B polypeptide 3-binding protein 1, REXO1, ELOABP1, KIAA1138, TCEB3BP1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The REXO1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSIYAL DCEMSYTTYG LELTRVTVVD TDVHVVYDTF VKPDNEIVDY NTRFSGVTEA DLADTSVTLR DVQAVLLSMF SADTILIGHS LESDLLALKV IHSTVVDTSV LFPHRLGLPY KRSLRNLMAD YLRQIIQDNV DGHSSSEDAG ACMHLVIWKV REDAKTKR

REXO1 is an exonuclease domain-containing protein which binds to Elongin. The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. REXO1 is composed of 1221 amino acids and its mRNA is ubiquitously expressed. REXO1 is a putative stem cell marker and is highly expressed in embryonic and adult stem cells.

REXO1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (1060-1221a.a) and having a molecular mass of 22.3kDa. REXO1 is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:REXO1: Seems to have no detectable effect on transcription elongation in vitro. Belongs to the REXO1/REXO3 family.Protein type: Hydrolase; EC 3.1.-.-Chromosomal Location of Human Ortholog: 19p13.3Cellular Component: nucleoplasmMolecular Function: nucleic acid binding; exonuclease activity
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q8N1G1
NCBI GenInfo Identifier:145199237
NCBI Gene ID:57455
NCBI Accession:NP_065746.3
UniProt Secondary Accession:Q8N1G1,Q9ULT2
UniProt Related Accession:Q8N1G1
Molecular Weight:131,510 Da
NCBI Full Name:RNA exonuclease 1 homolog
NCBI Synonym Full Names:REX1, RNA exonuclease 1 homolog
NCBI Official Symbol:REXO1  
NCBI Official Synonym Symbols:REX1; ELOABP1; EloA-BP1; TCEB3BP1  
NCBI Protein Information:RNA exonuclease 1 homolog
UniProt Protein Name:RNA exonuclease 1 homolog
UniProt Synonym Protein Names:Elongin-A-binding protein 1; EloA-BP1; Transcription elongation factor B polypeptide 3-binding protein 1
Protein Family:Redox-sensing transcriptional repressor
UniProt Gene Name:REXO1  
UniProt Entry Name:REXO1_HUMAN
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