Human RBP1 Recombinant Protein (RPPB0934)
- SKU:
- RPPB0934
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- RBP1
- Synonyms:
- Retinol binding protein 1 cellular
- CRBP
- CRBP1
- CRABP-I
- Source:
- Escherichia Coli
- Uniprot:
- P09455
Description
| Product Name: | Human RBP1 Recombinant Protein |
| Product Code: | RPPB0934 |
| Size: | 10µg |
| Species: | Human |
| Target: | RBP1 |
| Synonyms: | Retinol binding protein 1 cellular, CRBP, CRBP1, CRABP-I, RBPC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | RBP1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 200mM NaCl, 2mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDPPAGF VRAGNPAVAA PQSPLSPEGA HFRAAHHPRS TGSRCPGSLQ PSRPLVANWL QSLPEMPVDF TGYWKMLVNE NFEEYLRALD VNVALRKIAN LLKPDKEIVQ DGDHMIIRTL STFRNYIMDF QVGKEFEEDL TGIDDRKCMT TVSWDGDKLQ CVQKGEKEGR GWTQWIEGDE LHLEMRVEGV VCKQVFKKVQ |
RBP1 is a member of the calycin superfamily and fatty-acid binding protein (FABP) family. RBP1 is the carrier protein which takes part in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Additionally, RBP1 performs as a bridging molecule to recruit histone deacetylases (HDACs) which is a forceful regulator of gene expression. RBP1 is found in almost all the tissues with higher expression in pancreas, adrenal gland and pituitary gland, fetal liver and adult ovary.
RBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-197 a.a.) and having a molecular mass of 24.7kDa.RBP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496). |
| NCBI Summary: | This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | P09455 |
| NCBI GenInfo Identifier: | 132387 |
| NCBI Gene ID: | 5947 |
| NCBI Accession: | P09455.2 |
| UniProt Secondary Accession: | P09455,Q6FGX8, A8K2Q0, B7Z7A0, E7EWV0, F2Z2F2, |
| UniProt Related Accession: | P09455 |
| Molecular Weight: | 21000 |
| NCBI Full Name: | Retinol-binding protein 1 |
| NCBI Synonym Full Names: | retinol binding protein 1 |
| NCBI Official Symbol: | RBP1 |
| NCBI Official Synonym Symbols: | CRBP; RBPC; CRBP1; CRBPI; CRABP-I |
| NCBI Protein Information: | retinol-binding protein 1 |
| UniProt Protein Name: | Retinol-binding protein 1 |
| UniProt Synonym Protein Names: | Cellular retinol-binding protein; CRBP; Cellular retinol-binding protein I; CRBP-I |
| Protein Family: | Receptor binding protein |
| UniProt Gene Name: | RBP1 |
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