Human RAB32 Recombinant Protein (RPPB4360)

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SKU:
RPPB4360
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
RAB32
Synonyms:
RAB32 member RAS oncogene family
Synonyms:
ras-related protein Rab-32
Source:
Escherichia Coli
Uniprot:
Q13637
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Description

Product Name:Human RAB32 Recombinant Protein
Product Code:RPPB4360
Size:20µg
Species:Human
Target:RAB32
Synonyms:RAB32 member RAS oncogene family, ras-related protein Rab-32.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The RAB32 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 0.2M NaCl, 0.2M EDTA and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAGGGA GDPGLGAAAA PAPETREHLF KVLVIGELGV GKTSIIKRYV HQLFSQHYRA TIGVDFALKV LNWDSRTLVR LQLWDIAGQE RFGNMTRVYY KEAVGAFVVF DISRSSTFEA VLKWKSDLDS KVHLPNGSPI PAVLLANKCD QNKDSSQSPS QVDQFCKEHG FAGWFETSAK DNINIEEAAR FLVEKILVNH QSFPNEENDV DKIKLDQETL RAENKSQCC

RAB32 is a member of the small GTPase superfamily. RAB32 controls ER calcium management and disturbs the specific enhancement of calnexin on the MAM (mitochondria-associated membrane), however avoids affecting the ER distribution of protein-disulfide isomerase and mitofusin-2. Furthermore, RAB32 regulates the targeting of PKA (cAMP-dependent protein kinase) to mitochondrial and ER membranes and by inactivation or overexpression enhances the phosphorylation of Drp1 and Bad. Using a combination of its functions as a regulator of MAM properties and a PKA-anchoring protein, the activity and expression level of RAB32 define the speed of apoptosis onset.

RAB32 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 249 amino acids (1-225) and having a molecular mass of 27.6 kDa.RAB32 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RAB32: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Belongs to the small GTPase superfamily. Rab family.
UniProt Protein Details:

Protein type:G protein, monomeric; G protein; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 6q24.3

Cellular Component: early endosome; melanosome; membrane; mitochondrion; phagocytic vesicle; trans-Golgi network

Molecular Function:GTP-dependent protein binding; GTPase activity; protein binding

Biological Process: antigen processing and presentation

NCBI Summary:The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
UniProt Code:Q13637
NCBI GenInfo Identifier:2833245
NCBI Gene ID:10981
NCBI Accession:Q13637.3
UniProt Related Accession:Q13637
Molecular Weight:24,997 Da
NCBI Full Name:Ras-related protein Rab-32
NCBI Synonym Full Names:RAB32, member RAS oncogene family
NCBI Official Symbol:RAB32  
NCBI Protein Information:ras-related protein Rab-32
UniProt Protein Name:Ras-related protein Rab-32
Protein Family:Ras-related protein
UniProt Gene Name:RAB32  
UniProt Entry Name:RAB32_HUMAN
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