Human RAB17 Recombinant Protein (RPPB5914)

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SKU:
RPPB5914
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
RAB17
Synonyms:
RAB17 member RAS oncogene family
Synonyms:
ras-related protein Rab-17
Synonyms:
FLJ12538
Source:
Escherichia Coli
Uniprot:
Q9H0T7
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Description

Product Name:Human RAB17 Recombinant Protein
Product Code:RPPB5914
Size:20µg
Species:Human
Target:RAB17
Synonyms:RAB17 member RAS oncogene family, ras-related protein Rab-17, FLJ12538.
Source:Escherichia Coli
Physical Appearance:RAB17 is supplied as a sterile filtered clear solution.
Formulation:RAB17 protein 0.5mg/ml is supplied in 20mM Tris-HCL, pH-8, 0.1M NaCl, 1mM DTT and 30% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAQAHRTPQP RAAPSQPRVF KLVLLGSGSV GKSSLALRYV KNDFKSILPT VGCAFFTKVV DVGATSLKLE IWDTAGQEKY HSVCHLYFRG ANAALLVYDI TRKDSFLKAQ QWLKDLEEEL HPGEVLVMLV GNKTDLSQER EVTFQEGKEF ADSQKLLFMETSAKLNHQVS EVFNTVAQEL LQRSDEEGQA LRGDAAVALN KGPARQAKCC AH

RAB17 is a member of the small GTPase superfamily which are found in several intracellular compartments and have a significant regulatory part in membrane trafficking. RAB17 regulates traffic through the apical recycling endosome, which indicates that RAB17 has a role in polarized arrangement in epithelial cells.

RAB17 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (1-212) and having a molecular mass of 25.6 kDa.The RAB17 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:RAB17: Might be involved in transcellular transport. Belongs to the small GTPase superfamily. Rab family.
UniProt Protein Details:

Protein type:G protein, monomeric; G protein, monomeric, Rab; G protein

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: recycling endosome; cell soma; recycling endosome membrane; basolateral plasma membrane; endocytic vesicle; apical plasma membrane; early endosome; dendrite; plasma membrane; melanosome; intracellular

Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding

Biological Process: filopodium formation; metabolic process; regulation of dendrite development; regulation of filopodium formation; transcytosis; endocytic recycling; melanosome transport; intracellular protein transport; regulation of synaptogenesis; regulation of endocytosis; establishment of melanosome localization; cilium biogenesis; Rab protein signal transduction; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor

NCBI Summary:The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]
UniProt Code:Q9H0T7
NCBI GenInfo Identifier:37999892
NCBI Gene ID:64284
NCBI Accession:Q9H0T7.2
UniProt Related Accession:Q9H0T7
Molecular Weight:23kDa
NCBI Full Name:Ras-related protein Rab-17
NCBI Synonym Full Names:RAB17, member RAS oncogene family
NCBI Official Symbol:RAB17  
NCBI Protein Information:ras-related protein Rab-17
UniProt Protein Name:Ras-related protein Rab-17
Protein Family:Ras-related protein
UniProt Gene Name:RAB17  
UniProt Entry Name:RAB17_HUMAN
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