Human PTP4A3 Recombinant Protein (RPPB2226)
- SKU:
- RPPB2226
- Product type:
- Recombinant Protein
- Size:
- 50ug
- Species:
- Human
- Target:
- PTP4A3
- Synonyms:
- Protein tyrosine phosphatase type IVA 3
- Protein-tyrosine phosphatase 4a3
- Protein-tyrosine phosphatase of regenerating liver 3
- PRL-3
- Source:
- Escherichia Coli
- Uniprot:
- O75365
Description
| Product Name: | Human PTP4A3 Recombinant Protein |
| Product Code: | RPPB2226 |
| Size: | 50µg |
| Species: | Human |
| Target: | PTP4A3 |
| Synonyms: | Protein tyrosine phosphatase type IVA 3, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3, PRL-R, PTP4A3, PRL3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PTP4A3 solution contains 20mM Tris-HCl buffer (pH8.0), 2mM EDTA, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRFKDPHTHKTRC CVM |
Protein Tyrosine Phosphatase Type IVA Member 3 (PTP4A3) is a member of a small class of prenylated protein tyrosine phosphatases (PTPs) which remove phosphate modifications from tyrosine residues on proteins. PTP4A3 enhances cell proliferation, cell motility and invasive activity. PTP4A3 functions as a protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. PTP4A3 is mostly expressed in cardiomyocytes and skeletal muscle; it is also found in the pancreas. PTP4A3 is always overexpressed in colon cancer metastasis. PTP4A3 is notably overexpressed in liver metastasis of colorectal cancer. High levels of PTP4A3 expression are linked to tumorigenesis and metastasis; therefore it is overexpressed in metastatic colorectal, ovarian, liver and skin cancers. PTP4A3 may be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. PTP4A3 is inhibited by sodium orthovanadate and peroxovanadium compounds.
PTP4A3 Human Recombinant fused with a 20 amino acids His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 193 amino acids (1-173 a.a.) and having a molecular mass of 21.6kDa.The PTP4A3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PTP4A3: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. Belongs to the protein-tyrosine phosphatase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: early endosome; plasma membrane Molecular Function:prenylated protein tyrosine phosphatase activity Biological Process: endothelial cell migration |
| NCBI Summary: | This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O75365 |
| NCBI GenInfo Identifier: | 68566154 |
| NCBI Gene ID: | 11156 |
| NCBI Accession: | O75365.2 |
| UniProt Secondary Accession: | O75365,Q8IVN5, Q99849, Q9BTW5, |
| UniProt Related Accession: | O75365 |
| Molecular Weight: | 173 |
| NCBI Full Name: | Protein tyrosine phosphatase type IVA 3 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase type IVA, member 3 |
| NCBI Official Symbol: | PTP4A3 |
| NCBI Official Synonym Symbols: | PRL3; PRL-3; PRL-R |
| NCBI Protein Information: | protein tyrosine phosphatase type IVA 3; protein-tyrosine phosphatase 4a3; potentially prenylated protein tyrosine phosphatase; protein-tyrosine phosphatase of regenerating liver 3 |
| UniProt Protein Name: | Protein tyrosine phosphatase type IVA 3 |
| UniProt Synonym Protein Names: | PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3 |
| UniProt Gene Name: | PTP4A3 |
| UniProt Entry Name: | TP4A3_HUMAN |
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