Human PTP4A1 Recombinant Protein (RPPB2224)

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SKU:
RPPB2224
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
PTP4A1
Synonyms:
Protein tyrosine phosphatase type IVA 1
Synonyms:
PTP(CAAXI)
Synonyms:
Protein-tyrosine phosphatase 4a1
Synonyms:
Protein-tyrosine phosphatase of regenerating liver 1
Source:
Escherichia Coli
Uniprot:
Q93096
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Description

Product Name:Human PTP4A1 Recombinant Protein
Product Code:RPPB2224
Size:20µg
Species:Human
Target:PTP4A1
Synonyms:Protein tyrosine phosphatase type IVA 1, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1, HH72, DKFZp779M0721.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PTP4A1 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC

Protein tyrosine phosphatase type IVA 1 (PTP4A1) is a cell signaling molecule that has regulatory roles in a variety of cellular processes. PTP4A1 is a unique nuclear PTP which is induced in regenerating liver and mitogen stimulated cells. PTP4A1 is primarily expressed in the spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines.

PTP4A1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 190 amino acids (1-170 a.a.) and having a molecular mass of 21.6kDa. The PTP4A1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:PTP4A1: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. Belongs to the protein-tyrosine phosphatase family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 6q12

Cellular Component: cytoplasm; internal side of plasma membrane; nucleus

Molecular Function:protein tyrosine phosphatase activity

Biological Process: positive regulation of cell migration

NCBI Summary:This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
UniProt Code:Q93096
NCBI GenInfo Identifier:68566217
NCBI Gene ID:7803
NCBI Accession:Q93096.2
UniProt Secondary Accession:Q93096,O00648, Q49A54, B2R6C8,
UniProt Related Accession:Q93096
Molecular Weight:19,815 Da
NCBI Full Name:Protein tyrosine phosphatase type IVA 1
NCBI Synonym Full Names:protein tyrosine phosphatase type IVA, member 1
NCBI Official Symbol:PTP4A1  
NCBI Official Synonym Symbols:HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)  
NCBI Protein Information:protein tyrosine phosphatase type IVA 1
UniProt Protein Name:Protein tyrosine phosphatase type IVA 1
UniProt Synonym Protein Names:PTP(CAAXI); Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PRL-1
Protein Family:Protein tyrosine phosphatase
UniProt Gene Name:PTP4A1  
UniProt Entry Name:TP4A1_HUMAN
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