Human PRRX1 Recombinant Protein (RPPB4299)

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SKU:
RPPB4299
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PRRX1
Synonyms:
AGOTC
Synonyms:
PHOX1
Synonyms:
PMX1
Synonyms:
PRX-1
Source:
Escherichia Coli
Uniprot:
P54821
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Description

Product Name:Human PRRX1 Recombinant Protein
Product Code:RPPB4299
Size:10µg
Species:Human
Target:PRRX1
Synonyms:AGOTC, PHOX1, PMX1, PRX-1, PRX1, Paired mesoderm homeoboxprotein 1, Homeobox protein PHOX1, Paired-related homeobox protein 1, PRRX1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:PRRX1 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMTSSYG HVLERQPALG GRLDSPGNLD TLQAKKNFSV SHLLDLEEAGDMVAAQADEN VGEAGRSLLE SPGLTSGSDT PQQDNDQLNS EEKKKRKQRR NRTTFNSSQL QALERVFERT HYPDAFVREDLARRVNLTEA RVQVWFQNRR AKFRRNERAM LANKNASLLK SYSGDVTAVE QPIVPRPAPR PTDYLSWGTA SPYRSSSLPRCCLHEGLHNG F

PRRX1is part of the paired family of homeobox proteins. PRRX1 functions as atranscription co-activator, enhancing the DNA-binding activity of serum responsefactor, a protein required for the induction of genes by growth anddifferentiation factors. PRRX1 also regulates muscle creatine kinase, andtherefore has a part in the establishment of diverse mesodermal muscle types. Theprotein binds to an A/T-rich element in the muscle creatine enhancer. Among thediseases associated with PRRX1 are agnathia-otocephaly complex, and pleomorphicliposarcoma.

PRRX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 241 amino acids (1-217 a.a) and having a molecular mass of 26.9kDa.PRRX1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PRRX1: Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. Defects in PRRX1 are the cause of agnathia-otocephaly complex (AGOTC). AGOTC is a rare condition characterized by mandibular hypoplasia or agnathia, ventromedial auricular malposition (melotia) and/or auricular fusion (synotia), and microstomia with oroglossal hypoplasia or aglossia. Holoprosencephaly is the most commonly identified association, but skeletal, genitourinary, and cardiovascular anomalies, and situs inversus have been reported. The disorder is almost always lethal. Belongs to the paired homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: nucleolus; nucleus

Molecular Function:transcription coactivator activity

Disease: Agnathia-otocephaly Complex

NCBI Summary:The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]
UniProt Code:P54821
NCBI GenInfo Identifier:6174916
NCBI Gene ID:5396
NCBI Accession:P54821.2
UniProt Secondary Accession:P54821,O60807, B5BUM7,
UniProt Related Accession:P54821
Molecular Weight:24,396 Da
NCBI Full Name:Paired mesoderm homeobox protein 1
NCBI Synonym Full Names:paired related homeobox 1
NCBI Official Symbol:PRRX1  
NCBI Official Synonym Symbols:PMX1; PRX1; AGOTC; PHOX1; PRX-1  
NCBI Protein Information:paired mesoderm homeobox protein 1
UniProt Protein Name:Paired mesoderm homeobox protein 1
UniProt Synonym Protein Names:Homeobox protein PHOX1; Paired-related homeobox protein 1; PRX-1
Protein Family:Paired mesoderm homeobox protein
UniProt Gene Name:PRRX1  
UniProt Entry Name:PRRX1_HUMAN
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