Human PRAP1 Recombinant Protein (RPPB4288)

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SKU:
RPPB4288
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PRAP1
Synonyms:
Proline-rich acidic protein 1
Synonyms:
Epididymis tissue protein Li 178
Synonyms:
Uterine-specific proline-rich acidic protein
Synonyms:
PRAP1
Source:
Escherichia Coli
Uniprot:
Q96NZ9
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Description

Product Name:Human PRAP1 Recombinant Protein
Product Code:RPPB4288
Size:10µg
Species:Human
Target:PRAP1
Synonyms:Proline-rich acidic protein 1, Epididymis tissue protein Li 178, Uterine-specific proline-rich acidic protein, PRAP1, UPA, PRO1195.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:PRAP1 filtered (0.4 µm) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.
Solubility:It is recommended to add 200µl deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. PRAP1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASVPAPKVPIKM QVKHWPSEQD PEKAWGARVV EPPEKDDQLV VLFPVQKPKL LTTEEKPRGQ GRGPILPGTK AWMETEDTLG HVLSPEPDHD SLYHPPPEED QGEERPRLWV MPNHQVLLGP EEDQDHIYHP Q

Proline-rich acidic protein 1 (PRAP1) is essential for maintaining homeostasis in epithelial cells e.g. in liver or gastrointestinal tract. PRAP1 is abundantly expressed in the epithelial cells of the liver, kidney, gastrointestinal tract and cervix. PRAP1 is notably down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues.

PRAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 21-151) containing 141 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 16.2kDa (calculated).

UniProt Protein Function:PRAP1: May play an important role in maintaining normal growth homeostasis in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: extracellular region

Molecular Function:protein binding

UniProt Code:Q96NZ9
NCBI GenInfo Identifier:223633959
NCBI Gene ID:118471
NCBI Accession:NP_660203.3
UniProt Secondary Accession:Q96NZ9,Q5VWY4, Q7Z4X5, Q8IWR3, Q8NCS2, B7ZL57, B7ZL58 E9KL31,
UniProt Related Accession:Q96NZ9
Molecular Weight:16,332 Da
NCBI Full Name:proline-rich acidic protein 1 isoform 1
NCBI Synonym Full Names:proline-rich acidic protein 1
NCBI Official Symbol:PRAP1  
NCBI Official Synonym Symbols:UPA; PRO1195  
NCBI Protein Information:proline-rich acidic protein 1
UniProt Protein Name:Proline-rich acidic protein 1
UniProt Synonym Protein Names:Epididymis tissue protein Li 178; Uterine-specific proline-rich acidic protein
Protein Family:Proline-rich acidic protein
UniProt Gene Name:PRAP1  
UniProt Entry Name:PRAP1_HUMAN
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