Human PNPO Recombinant Protein (RPPB2131)
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주문- SKU:
- RPPB2131
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- PNPO
- Synonyms:
- Pyridoxine-5'-phosphate oxidase
- Synonyms:
- Pyridoxamine-phosphate oxidase
- Synonyms:
- PNPO
- Synonyms:
- PDXPO
- Source:
- Escherichia Coli
- Uniprot:
- Q9NVS9
Description
| Product Name: | Human PNPO Recombinant Protein |
| Product Code: | RPPB2131 |
| Size: | 20µg |
| Species: | Human |
| Target: | PNPO |
| Synonyms: | Pyridoxine-5'-phosphate oxidase, Pyridoxamine-phosphate oxidase, PNPO, PDXPO, FLJ10535. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PNPO solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.1M NaCl and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MDPVKQFAAW FEEAVQCPDI GEANAMCLAT CTRDGKPSAR MLLLKGFGKD GFRFFTNFES RKGKELDSNP FASLVFYWEP LNRQVRVEGP VKKLPEEEAE CYFHSRPKSS QIGAVVSHQS SVIPDREYLR KKNEELEQLY QDQEVPKPKS WGGYVLYPQV MEFWQGQTNR LHDRIVFRRG LPTGDSPLGP MTHRGEEDWL YERLAP |
Pyridoxine-5'-phosphate oxidase (PNPO) is the rate-limiting enzyme in vitamin B6 synthesis. Vitamin B6 (Pyridoxal 5-prime-phosphate or PLP) is vital for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts.Vitamin B6 is an essential co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in the PNPO gene result in PNPO deficiency, a form of neonatal epileptic encephalopathy.
PNPO Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 226 amino acids (57-261 a.a.) and having a molecular mass of 25.9kDa. The PNPO is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PNPO: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). Defects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency); also known as PNPO-related neonatal epileptic encephalopathy. The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine. Belongs to the pyridoxamine 5'-phosphate oxidase family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.4.3.5; Cofactor and Vitamin Metabolism - vitamin B6 Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:pyridoxamine-phosphate oxidase activity Biological Process: positive regulation of defense response to virus by host; pyridoxal phosphate biosynthetic process; vitamin B6 metabolic process Disease: Pyridoxamine 5-prime-phosphate Oxidase Deficiency |
| NCBI Summary: | The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q9NVS9 |
| NCBI GenInfo Identifier: | 37082126 |
| NCBI Gene ID: | 55163 |
| NCBI Accession: | Q9NVS9.1 |
| UniProt Secondary Accession: | Q9NVS9,B4E0V0, B4E152, B4E1D7, D3DTT9, |
| UniProt Related Accession: | Q9NVS9 |
| Molecular Weight: | 25,200 Da |
| NCBI Full Name: | Pyridoxine-5'-phosphate oxidase |
| NCBI Synonym Full Names: | pyridoxamine 5'-phosphate oxidase |
| NCBI Official Symbol: | PNPO |
| NCBI Official Synonym Symbols: | PDXPO; HEL-S-302 |
| NCBI Protein Information: | pyridoxine-5'-phosphate oxidase |
| UniProt Protein Name: | Pyridoxine-5'-phosphate oxidase |
| UniProt Synonym Protein Names: | Pyridoxamine-phosphate oxidase |
| Protein Family: | Pyridoxine-5'-phosphate oxidase |
| UniProt Gene Name: | PNPO |
| UniProt Entry Name: | PNPO_HUMAN |
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