Human PNOC Recombinant Protein (RPPB4266)
- SKU:
- RPPB4266
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- PNOC
- Synonyms:
- Prepronociceptin
- Nocistatin
- OFQ
- Pre-Pro-N/OFQ
- Source:
- Escherichia Coli
- Uniprot:
- Q13519
Description
| Product Name: | Human PNOC Recombinant Protein |
| Product Code: | RPPB4266 |
| Size: | 20µg |
| Species: | Human |
| Target: | PNOC |
| Synonyms: | Prepronociceptin, Nocistatin, OFQ, Pre-Pro-N/OFQ,Pronociceptin, Orphanin FQ, Nociceptin, PpN/OFQ, N/OFQ, PPNOC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PNOC protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSCQRDCL TCQEKLHPAL DSFDLEVCIL ECEEKVFPSP LWTPCTKVMA RSSWQLSPAA PEHVAAALYQ PRASEMQHLR RMPRVRSLFQ EQEEPEPGME EAGEMEQKQL QKRFGGFTGA RKSARKLANQ KRFSEFMRQY LVLSMQSSQR RRTLHQNGNV |
Prepronociceptin (PNOC) is the ligand of the opioid receptor-like receptor (OPRL1). PNOC functions as a transmitter in the brain by modulating nociceptive and locomotor behavior. The PNOC protein may also be involved in neuronal differentiation and development.
PNOC Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (20-176) and having a molecular mass of 20.6kDa. PNOC is fused to a 23 amino acid His-tag at N-terminus.
| UniProt Protein Function: | PNOC: Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Belongs to the opioid neuropeptide precursor family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 8p21 Cellular Component: extracellular region Molecular Function:neuropeptide hormone activity; protein binding; opioid peptide activity Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; signal transduction |
| NCBI Summary: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q13519 |
| NCBI GenInfo Identifier: | 2494348 |
| NCBI Gene ID: | 5368 |
| NCBI Accession: | Q13519.1 |
| UniProt Related Accession: | Q13519 |
| Molecular Weight: | 13kDa; 20kDa |
| NCBI Full Name: | Prepronociceptin |
| NCBI Synonym Full Names: | prepronociceptin |
| NCBI Official Symbol: | PNOC |
| NCBI Official Synonym Symbols: | NOP; OFQ; N/OFQ; PPNOC; ppN/OFQ |
| NCBI Protein Information: | prepronociceptin |
| UniProt Protein Name: | Prepronociceptin |
| UniProt Synonym Protein Names: | Orphanin FQ; PPNOC |
| Protein Family: | Prepronociceptin |
| UniProt Gene Name: | PNOC |
| UniProt Entry Name: | PNOC_HUMAN |
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