Human PLEKHF2 Recombinant Protein (RPPB4260)

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SKU:
RPPB4260
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
PLEKHF2
Synonyms:
EAPF
Synonyms:
PHAFIN2
Synonyms:
ZFYVE18
Synonyms:
Pleckstrin homology domain-containing family F member 2
Source:
Escherichia Coli
Uniprot:
Q9H8W4
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Description

Product Name:Human PLEKHF2 Recombinant Protein
Product Code:RPPB4260
Size:20µg
Species:Human
Target:PLEKHF2
Synonyms:EAPF, PHAFIN2, ZFYVE18, Pleckstrin homology domain-containing family F member 2, PH domain-containing family F member 2, Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains, PH and FYVE domain-containing protein 2, Zinc finger FYVE domain-containing protein 18, PLEKHF2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PLEKHF2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMVDRLAN SEANTRRISI VENCFGAAGQ PLTIPGRVLI GEGVLTKLCR KKPKARQFFL FNDILVYGNI VIQKKKYNKQ HIIPLENVTI DSIKDEGDLR NGWLIKTPTK SFAVYAATAT EKSEWMNHIN KCVTDLLSKS GKTPSNEHAA VWVPDSEATV CMRCQKAKFT PVNRRHHCRK CGFVVCGPCS EKRFLLPSQS SKPVRICDFC YDLLSAGDMA TCQPARSDSY SQSLKSPLND MSDDDDDDDS SD

Pleckstrin Homology Domain Containing Family F Member 2, also known as PLEKHF2, contains 1 FYVE-type zinc finger and 1 PH domain. PLEKHF2 takes part in early endosome fusion upstream of RAB5, regulates receptor trafficking and fluid-phase transport. PLEKHF2 increases cellular sensitivity to TNF-induced apoptosis.

PLEKHF2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 272 amino acids (1-249 a.a) and having a molecular mass of 30.2kDa. PLEKHF2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PLEKHF2: a protein containing a PH domain and a FYVE zinc finger domain.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: transport vesicle

Molecular Function:protein binding

UniProt Code:Q9H8W4
NCBI GenInfo Identifier:74762744
NCBI Gene ID:79666
NCBI Accession:Q9H8W4.1
UniProt Related Accession:Q9H8W4
Molecular Weight:27,798 Da
NCBI Full Name:Pleckstrin homology domain-containing family F member 2
NCBI Synonym Full Names:pleckstrin homology and FYVE domain containing 2
NCBI Official Symbol:PLEKHF2  
NCBI Official Synonym Symbols:EAPF; PHAFIN2; ZFYVE18  
NCBI Protein Information:pleckstrin homology domain-containing family F member 2
UniProt Protein Name:Pleckstrin homology domain-containing family F member 2
UniProt Synonym Protein Names:Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains; EAPF; PH and FYVE domain-containing protein 2; Phafin-2; Phafin2; Zinc finger FYVE domain-containing protein 18
Protein Family:Pleckstrin homology domain-containing family
UniProt Gene Name:PLEKHF2  
UniProt Entry Name:PKHF2_HUMAN
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