Human PICK1 Recombinant Protein (RPPB2606)

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SKU:
RPPB2606
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PICK1
Synonyms:
ProteinInteracting With PRKCA 1
Synonyms:
PRKCABP
Synonyms:
Protein Kinase C-Alpha-Binding Protein
Synonyms:
ProteinInteracting With C Kinase 1
Source:
Escherichia Coli
Uniprot:
Q9NRD5
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Description

Product Name:Human PICK1 Recombinant Protein
Product Code:RPPB2606
Size:10µg
Species:Human
Target:PICK1
Synonyms:ProteinInteracting With PRKCA 1, PRKCABP, Protein Kinase C-Alpha-Binding Protein, ProteinInteracting With C Kinase 1, Protein Kinase C, Alpha Binding Protein, ProteinInteracting With PRKCA, PRKCA-Binding Protein, PICK, PRKCA-binding protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PICK1 protein solution (0.25mg/ml) containing Phosphatebuffered saline (pH7.4), 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSMFADLDYDIEEDKLGIP TVPGKVTLQK DAQNLIGISI GGGAQYCPCL YIVQVFDNTP AALDGTVAAG DEITGVNGRSIKGKTKVEVA KMIQEVKGEV TIHYNKLQAD PKQGMSLDIV LKKVKHRLVE NMSSGTADAL GLSRAILCNDGLVKRLEELE RTAELYKGMT EHTKNLLRAF YELSQTHRAF GDVFSVIGVR EPQPAASEAF VKFADAHRSIEKFGIRLLKT IKPMLTDLNT YLNKAIPDTR LTIKKYLDVK FEYLSYCLKV KEMDDEEYSC IALGEPLYRVSTGNYEYRLI LRCRQEARAR FSQMRKDVLE KMELLDQKHV QDIVFQLQRL VSTMSKYYND CYAVLRDADVFPIEVDLAHT TLAYGLNQEE FTDGEEEEEE EDTAAGEPSR DTRGAAGPLD KGGSWCDS

Protein Interacting with PRKCA 1, also known as PICK1 includes a PDZdomain, through which it interacts with protein kinase C, alpha (PRKCA). PICK1performs as an adaptor which binds to and arranges the subcellular localizationof various membrane proteins. PICK1 interacts with multiple glutamate receptorsubtypes, monoamine plasma membrane transporters, in addition to non-voltagegated sodium channels, and might target PRKCA to these membrane proteins and thereforeregulates their distribution as well as function. PICK1 has also been found to performas an anchoring protein which particularly targets PRKCA to mitochondria ina  ligand-specific manner.

PICK1 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 438 amino acids (1-415 a.a) and having a molecularmass of 49.0kDa. PICK1 is fused to a 23amino acid His-tag at N-terminus & purified by proprietary chromatographictechniques.

UniProt Protein Function:PICK1: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.
UniProt Protein Details:

Protein type:Cell development/differentiation; Ligand, receptor tyrosine kinase; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: presynaptic membrane; Golgi apparatus; postsynaptic membrane; neuron projection; cytoskeleton; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; synapse; cell junction

Molecular Function:actin filament binding; protein C-terminus binding; identical protein binding; protein domain specific binding; protein binding; enzyme binding; G-protein-coupled receptor binding; protein kinase C binding; metal ion binding; ATPase activity; receptor binding

Biological Process: glial cell development; cellular response to glucose starvation; synaptic transmission; DNA methylation during gametogenesis; monoamine transport; positive regulation of receptor internalization; protein kinase C activation; retrograde vesicle-mediated transport, Golgi to ER; DNA methylation during embryonic development; neuronal ion channel clustering; protein amino acid phosphorylation; receptor clustering; protein targeting

NCBI Summary:The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NRD5
NCBI GenInfo Identifier:22095990
NCBI Gene ID:9463
NCBI Accession:Q9NRD5.2
UniProt Secondary Accession:Q9NRD5,O95906, B3KS52,
UniProt Related Accession:Q9NRD5
Molecular Weight:415
NCBI Full Name:PRKCA-binding protein
NCBI Synonym Full Names:protein interacting with PRKCA 1
NCBI Official Symbol:PICK1  
NCBI Official Synonym Symbols:PICK; PRKCABP  
NCBI Protein Information:PRKCA-binding protein; protein interacting with C kinase 1; protein kinase C-alpha-binding protein
UniProt Protein Name:PRKCA-binding protein
UniProt Synonym Protein Names:Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein
Protein Family:PRKCA-binding protein
UniProt Gene Name:PICK1  
UniProt Entry Name:PICK1_HUMAN
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