Human PHB2 Recombinant Protein (RPPB4240)

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SKU:
RPPB4240
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
PHB2
Synonyms:
BAP
Synonyms:
Bap37
Synonyms:
BCAP37
Synonyms:
p22
Source:
Escherichia Coli
Uniprot:
Q99623
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Description

Product Name:Human PHB2 Recombinant Protein
Product Code:RPPB4240
Size:20µg
Species:Human
Target:PHB2
Synonyms:BAP, Bap37, BCAP37, p22, PNAS-141, REA, Prohibitin-2, B-cell receptor-associated protein BAP37, D-prohibitin, Repressor of estrogen receptor activity, PHB2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The PHB2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAQNLKD LAGRLPAGPR GMGTALKLLL GAGAVAYGVR ESVFTVEGGH RAIFFNRIGG VQQDTILAEG LHFRIPWFQY PIIYDIRARP RKISSPTGSK DLQMVNISLR VLSRPNAQEL PSMYQRLGLD YEERVLPSIV NEVLKSVVAK FNASQLITQR AQVSLLIRRE LTERAKDFSL ILDDVAITEL SFSREYTAAV EAKQVAQQEA QRAQFLVEKA KQEQRQKIVQ AEGEAEAAKM LGEALSKNPG YIKLRKIRAA QNISKTIATS QNRIYLTADN LVLNLQDESF TRGSDSLIKG KK

Prohibitin 2, also known as PHB2, mediates transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases by similarity. PHB2 functions as an estrogen receptor (ER)-selective coregulator which potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 which is involved in regulating mitochondrial respiration activity and in aging, competes with NCOA1 for modulation of ER transcriptional activity.

PHB2 Human Recombinant produced in E. coli is a single polypeptide chain containing 322 amino acids (1-299) and having a molecular mass of 35.7kDa. PHB2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:BAP37: a protein of the band 7 family. This family includes the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. A repressor of estrogen receptor (ER) activity. Reverses steroid receptor coactivator 1 enhancement of ER activity. May play a role in determining the sensitivity of estrogen target cells to antiestrogen and estrogen therapy.
UniProt Protein Details:

Protein type:Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: protein complex; nuclear matrix; mitochondrion; mitochondrial inner membrane; nucleus

Molecular Function:protein binding; estrogen receptor binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; negative regulation of mammary gland epithelial cell proliferation; negative regulation of estrogen receptor signaling pathway

UniProt Code:Q99623
NCBI GenInfo Identifier:74752151
NCBI Gene ID:
NCBI Accession:Q99623.2
Molecular Weight:
NCBI Full Name:Prohibitin-2
UniProt Protein Name:Prohibitin-2
UniProt Synonym Protein Names:B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity
Protein Family:Readthrough protein
UniProt Gene Name:PHB2  
UniProt Entry Name:PHB2_HUMAN
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