Human PDXK Recombinant Protein (RPPB2599)
- SKU:
- RPPB2599
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- PDXK
- Synonyms:
- Pyridoxal kinase
- Pyridoxine kinase
- PDXK
- C21orf124
- Source:
- Escherichia Coli
- Uniprot:
- O00764
Description
| Product Name: | Human PDXK Recombinant Protein |
| Product Code: | RPPB2599 |
| Size: | 10µg |
| Species: | Human |
| Target: | PDXK |
| Synonyms: | Pyridoxal kinase, Pyridoxine kinase, PDXK, C21orf124, C21orf97, PKH, PNK, PRED79, FLJ31940, FLJ37311, MGC15873, MGC31754, MGC52346, DKFZp566A071. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PDXK solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMEEECR VLSIQSHVIR GYVGNRAATF PLQVLGFEID AVNSVQFSNH TGYAHWKGQV LNSDELQELY EGLRLNNMNK YDYVLTGYTR DKSFLAMVVD IVQELKQQNP RLVYVCDPVL GDKWDGEGSM YVPEDLLPVY KEKVVPLADI ITPNQFEAELLSGRKIHSQE EALRVMDMLH SMGPDTVVIT SSDLPSPQGS NYLIVLGSQR RRNPAGSVVM ERIRMDIRKV DAVFVGTGDL FAAMLLAWTH KHPNNLKVAC EKTVSTLHHV LQRTIQCAKA QAGEGVRPSP MQLELRMVQS KRDIEDPEIV VQATVL |
PDXK converts vitamin B6 to Pyridoxal-5-phosphate (PLP), which is a vital cofactor in the intermediate metabolism of amino acids and neurotransmitters. PDXK is cytoplasmic and probably acts as a homodimer. The biological validity of the alternatively spliced transcript variants has not been determined.
PDXK Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 336 amino acids (1-312 a.a.) and having a molecular mass of 37.6kDa. The PDXK is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PDXK: Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Belongs to the pyridoxine kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, other; Cofactor and Vitamin Metabolism - vitamin B6; EC 2.7.1.35 Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:ATP binding; lithium ion binding; magnesium ion binding; potassium ion binding; protein homodimerization activity; pyridoxal kinase activity; pyridoxal phosphate binding; sodium ion binding; zinc ion binding Biological Process: cell proliferation; pyridoxal 5'-phosphate salvage; pyridoxal phosphate biosynthetic process; vitamin B6 metabolic process |
| NCBI Summary: | The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00764 |
| NCBI GenInfo Identifier: | 2811007 |
| NCBI Gene ID: | 8566 |
| NCBI Accession: | O00764.1 |
| UniProt Secondary Accession: | O00764,Q7Z2Y0, Q9BS02, |
| UniProt Related Accession: | O00764 |
| Molecular Weight: | 26,827 Da |
| NCBI Full Name: | Pyridoxal kinase |
| NCBI Synonym Full Names: | pyridoxal (pyridoxine, vitamin B6) kinase |
| NCBI Official Symbol: | PDXK |
| NCBI Official Synonym Symbols: | PKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124 |
| NCBI Protein Information: | pyridoxal kinase |
| UniProt Protein Name: | Pyridoxal kinase |
| UniProt Synonym Protein Names: | Pyridoxine kinase |
| Protein Family: | Pyridoxine kinase |
| UniProt Gene Name: | PDXK |
| UniProt Entry Name: | PDXK_HUMAN |
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