Human PDLIM1 Recombinant Protein (RPPB4215)

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SKU:
RPPB4215
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
PDLIM1
Synonyms:
PDZ And LIM Domain Protein 1
Synonyms:
Carboxyl Terminal LIM Domain Protein 1
Synonyms:
Epididymis Secretory Protein Li 112m
Synonyms:
C-Terminal LIM Domain Protein 1
Source:
Escherichia Coli
Uniprot:
O00151
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Description

Product Name:Human PDLIM1 Recombinant Protein
Product Code:RPPB4215
Size:25µg
Species:Human
Target:PDLIM1
Synonyms:PDZ And LIM Domain Protein 1, Carboxyl Terminal LIM Domain Protein 1, Epididymis Secretory Protein Li 112m, C-Terminal LIM Domain Protein 1, LIM Domain Protein CLP-36, hCLIM1, HEL-S-112, CLP-36, Elfin.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The PDLIM1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.1M NaCl, 1mM DTT, 2mM EDTA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEFMTTQQ IDLQGPGPWG FRLVGGKDFE QPLAISRVTP GSKAALANLC IGDVITAIDG ENTSNMTHLE AQNRIKGCTD NLTLTVARSE HKVWSPLVTE EGKRHPYKMN LASEPQEVLH IGSAHNRSAM PFTASPASST TARVITNQYN NPAGLYSSEN ISNFNNALES KTAASGVEAN SRPLDHAQPP SSLVIDKESE VYKMLQEKQE LNEPPKQSTS FLVLQEILES EEKGDPNKPS GFRSVKAPVT KVAASIGNAQ KLPMCDKCGT GIVGVFVKLR DRHRHPECYV CTDCGTNLKQ KGHFFVEDQI YCEKHARERV TPPEGYEVVT VFPK

PDLIM1, a cytoplasmic protein linked to the cytoskeleton, belongs to the enigma protein family. PDLIM1 holds two protein interacting domains - PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. PDLIM1 enables bringing other LIM interacting proteins to the cytoskeleton. Pseudogenes related to PDLIM1 are situated on chromosomes 3, 14 and 17.

PDLIM1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 354 amino acids (1-329) and having a molecular mass of 38.7 kDa. PDLIM1 is fused to a 25 amino acid His-tag at N-terminus.

UniProt Protein Function:CLIM1: a cytoskeletal adaptor protein that bring other proteins to the cytoskeleton. Interacts with alpha-actinins 1, 2 and 4. Recruits the Clik1 kinase to actin stress fibers in nonmuscle cells. Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 10q23.1

Cellular Component: transcription factor complex; cytoskeleton; focal adhesion; cytoplasm

Molecular Function:zinc ion binding; transcription coactivator activity

Biological Process: regulation of transcription, DNA-dependent; response to hypoxia; response to oxidative stress

NCBI Summary:This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012]
UniProt Code:O00151
NCBI GenInfo Identifier:20178312
NCBI Gene ID:9124
NCBI Accession:O00151.4
UniProt Secondary Accession:O00151,Q5VZH5, Q9BPZ9, B2RBS6,
UniProt Related Accession:O00151
Molecular Weight:329
NCBI Full Name:PDZ and LIM domain protein 1
NCBI Synonym Full Names:PDZ and LIM domain 1
NCBI Official Symbol:PDLIM1  
NCBI Official Synonym Symbols:CLIM1; CLP36; CLP-36; hCLIM1; HEL-S-112  
NCBI Protein Information:PDZ and LIM domain protein 1; elfin; LIM domain protein CLP-36; epididymis secretory protein Li 112; carboxyl terminal LIM domain protein 1
UniProt Protein Name:PDZ and LIM domain protein 1
UniProt Synonym Protein Names:C-terminal LIM domain protein 1; Elfin; LIM domain protein CLP-36
Protein Family:PDZ and LIM domain protein
UniProt Gene Name:PDLIM1  
UniProt Entry Name:PDLI1_HUMAN
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