Human PDE6H Recombinant Protein (RPPB2079)

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SKU:
RPPB2079
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PDE6H
Synonyms:
Phosphodiesterase 6H
Synonyms:
CGMP-Specific
Synonyms:
Cone
Synonyms:
Gamma
Source:
Escherichia Coli
Uniprot:
Q13956
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Description

Product Name:Human PDE6H Recombinant Protein
Product Code:RPPB2079
Size:10µg
Species:Human
Target:PDE6H
Synonyms:Phosphodiesterase 6H, CGMP-Specific, Cone, Gamma, RetinalCone Rhodopsin-Sensitive CGMP 3',5'-Cyclic Phosphodiesterase, Subunit Gamma, EC3.1.4.35, EC 3.1.4.17, RCD3, GMP-PDE Gamma, ACHM6, PDE6H.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PDE6H protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol, 2mM DTT and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSDNTTL PAPASNQGPT TPRKGPPKFK QRQTRQFKSK PPKKGVKGFGDDIPGMEGLG TDITVICPWE AFSHLELHEL AQFGII

PDE6Hbelongs to the rod/cone cGMP-PDE gamma subunit family, which selectivelycatalyze the hydrolysis of 3 cyclic phosphate bonds in adenosine and/or guanine3,5 cyclic monophosphate (cAMP and/or cGMP). This family regulates the cellularlevels, localization and duration of action of these second messengers bycontrolling the rate of their degradation. PDE6H is the inhibitory (or gamma)subunit of the cone-specific cGMP phosphodiesterase, which is a tetramercomposed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).PDE6H is particularly expressed in the retina, and is implicated in thetransmission and amplification of the visual signal. Mutations in PDE6H havebeen associated with retinal cone dystrophy type 3A.

PDE6H Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 106 amino acids (1-83 a.a) andhaving a molecular mass of 11.5 kDa.PDE6H is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
UniProt Protein Details:
NCBI Summary:This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010]
UniProt Code:Q13956
NCBI GenInfo Identifier:5453868
NCBI Gene ID:5149
NCBI Accession:NP_006196
UniProt Secondary Accession:Q13956,Q52LY7
UniProt Related Accession:Q13956
Molecular Weight:11.5 kDa (106aa) confirmed by MALDI-TOF
NCBI Full Name:retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
NCBI Synonym Full Names:phosphodiesterase 6H
NCBI Official Symbol:PDE6H  
NCBI Official Synonym Symbols:RCD3; ACHM6  
NCBI Protein Information:retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
UniProt Protein Name:Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
UniProt Synonym Protein Names:
Protein Family:Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase
UniProt Gene Name:PDE6H  
UniProt Entry Name:
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