Human PDCD1LG2 Recombinant Protein (RPPB4208)

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SKU:
RPPB4208
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PDCD1LG2
Synonyms:
Programmed Cell Death 1 Ligand 2
Synonyms:
B7 Dendritic Cell Molecule
Synonyms:
Programmed Death Ligand 2
Synonyms:
Butyrophilin B7-DC
Source:
Sf9 Insect cells
Uniprot:
Q9BQ51
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Description

Product Name:Human PDCD1LG2 Recombinant Protein
Product Code:RPPB4208
Size:10µg
Species:Human
Target:PDCD1LG2
Synonyms:Programmed Cell Death 1 Ligand 2, B7 Dendritic Cell Molecule, Programmed Death Ligand 2, Butyrophilin B7-DC, PDCD1 Ligand 2, PDCD1L2, B7-DC, CD273, PD-L2,B7DC, PDL2, PD-1-Ligand 2, CD273 Antigen, PD-1 Ligand 2, BA574F11.2, Btdc.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PDCD1LG2 protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPLFTVTVP KELYIIEHGS NVTLECNFDT GSHVNLGAIT ASLQKVENDT SPHRERATLL EEQLPLGKAS FHIPQVQVRD EGQYQCIIIY GVAWDYKYLT LKVKASYRKI NTHILKVPET DEVELTCQAT GYPLAEVSWP NVSVPANTSH SRTPEGLYQV TSVLRLKPPP GRNFSCVFWN THVRLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH

Programmed cell death 1 ligand 2 (PDCD1LG2) which takes part in the costimulatory signal, is necessary for T-cell proliferation. PDCD1LG2 is also involved in IFNG production in a PDCD1-independent way. The interaction with PDCD1 inhibits T-cell proliferation by preventing cytokine production and cell cycle progression.

PDCD1LG2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 423 amino acids (20-200a.a.) and having a molecular mass of 47.7kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).PDCD1LG2 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
UniProt Code:Q9BQ51
NCBI GenInfo Identifier:73917618
NCBI Gene ID:80380
NCBI Accession:Q9BQ51.2
UniProt Secondary Accession:Q9BQ51,Q14CN8, Q5T7Z6, Q6JXL8, Q6JXL9,
UniProt Related Accession:Q9BQ51
Molecular Weight:20,745 Da
NCBI Full Name:Programmed cell death 1 ligand 2
NCBI Synonym Full Names:programmed cell death 1 ligand 2
NCBI Official Symbol:PDCD1LG2  
NCBI Official Synonym Symbols:B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2  
NCBI Protein Information:programmed cell death 1 ligand 2
UniProt Protein Name:Programmed cell death 1 ligand 2
UniProt Synonym Protein Names:Butyrophilin B7-DC; B7-DC; CD_antigen: CD273
Protein Family:Programmed cell death
UniProt Gene Name:PDCD1LG2  
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