Human OLR1 Recombinant Protein (RPPB4156)

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SKU:
RPPB4156
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
OLR1
Synonyms:
OxidizedLow Density Lipoprotein Receptor 1
Synonyms:
C-Type Lectin Domain Family 8 Member A
Synonyms:
Lectin-TypeOxidized LDL Receptor 1
Synonyms:
CLEC8A
Source:
Sf9 Insect cells
Uniprot:
P78380
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Description

Product Name:Human OLR1 Recombinant Protein
Product Code:RPPB4156
Size:10µg
Species:Human
Target:OLR1
Synonyms:OxidizedLow Density Lipoprotein Receptor 1, C-Type Lectin Domain Family 8 Member A, Lectin-TypeOxidized LDL Receptor 1, CLEC8A, HLOX-1, LOX1, Oxidised Low Density Lipoprotein(Lectin-Like) Receptor 1, Oxidized Low Density Lipoprotein (Lectin-Like)Receptor 1, Oxidized Low-Density Lipoprotein Receptor 1, Soluble Form, OxidizedLow-Density Lipoprotein Receptor 1, Scavenger Receptor Class E, Member 1, Lectin-LikeOxidized LDL Receptor 1, Lectin-Like OxLDL Receptor 1, Ox LDL Receptor 1, Ox-LDLReceptor 1, SCARE1, LOXIN, SLOX1, LOX-1, Oxidized low-density lipoproteinreceptor 1, Ox-LDL receptor 1, C-type lectin domain family 8 member A, LOX-1, Lectin-likeoxLDL receptor 1, hLOX-1, Lectin-type oxidized LDL receptor 1.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:OLR1protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10%glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:ADPMQLSQVSDLLTQEQANL THQKKKLEGQ ISARQQAEEA SQESENELKE MIETLARKLN EKSKEQMELH HQNLNLQETLKRVANCSAPC PQDWIWHGEN CYLFSSGSFN WEKSQEKCLS LDAKLLKINS TADLDFIQQA ISYSSFPFWMGLSRRNPSYP WLWEDGSPLM PHLFRVRGAVSQTYPSGTCA YIQRGAVYAE NCILAAFSIC QKKANLRAQH HHHHH

OLR1 is a type II membrane protein which belongs to the C-type lectin family and performs as a cell-surface receptor for Ox-LDL. Ox-LDL has a part in early ather-osclerosis, which includes the transformation of monocyte-derived macro-phages to foam cells in atherosclerotic lesions. In addition, OLR1 protein triggers the activation of the NFkB signal transduction pathway.

OLR1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 225 amino acids (58-273a.a) and having a molecular mass of 25.8kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). OLR1 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:OLR1: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria. Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility. OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: nucleoplasm; membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; receptor complex; lipid raft

Molecular Function:low-density lipoprotein receptor activity; protein binding; carbohydrate binding

Biological Process: cell death; receptor-mediated endocytosis; leukocyte adhesion; response to hydrogen peroxide; blood circulation; lipoprotein metabolic process; inflammatory response; proteolysis; blood coagulation; leukocyte migration

Disease: Myocardial Infarction, Susceptibility To

NCBI Summary:This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
UniProt Code:P78380
NCBI GenInfo Identifier:73621335
NCBI Gene ID:4973
NCBI Accession:P78380.1
UniProt Secondary Accession:P78380,Q2PP00, Q7Z484, A8K7V9, B4DI48, G3V1I4,
UniProt Related Accession:P78380
Molecular Weight:21,425 Da
NCBI Full Name:Oxidized low-density lipoprotein receptor 1
NCBI Synonym Full Names:oxidized low density lipoprotein (lectin-like) receptor 1
NCBI Official Symbol:OLR1  
NCBI Official Synonym Symbols:LOX1; LOXIN; SLOX1; CLEC8A; SCARE1  
NCBI Protein Information:oxidized low-density lipoprotein receptor 1; hLOX-1; ox LDL receptor 1; lectin-type oxidized LDL receptor 1; scavenger receptor class E, member 1; C-type lectin domain family 8 member A; oxidized low-density lipoprotein receptor 1, soluble form
UniProt Protein Name:Oxidized low-density lipoprotein receptor 1
UniProt Synonym Protein Names:C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; hLOX-1; Lectin-type oxidized LDL receptor 1Cleaved into the following chain:Oxidized low-density lipoprotein receptor 1, soluble form
Protein Family:Oxidized low-density lipoprotein receptor
UniProt Gene Name:OLR1  
UniProt Entry Name:OLR1_HUMAN
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