Human NPM2 Recombinant Protein (RPPB4120)

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SKU:
RPPB4120
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
NPM2
Synonyms:
Nucleophosmin/nucleoplasmin 2
Synonyms:
nucleoplasmin-2
Source:
Escherichia Coli
Uniprot:
Q86SE8
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Description

Product Name:Human NPM2 Recombinant Protein
Product Code:RPPB4120
Size:10µg
Species:Human
Target:NPM2
Synonyms:Nucleophosmin/nucleoplasmin 2, nucleoplasmin-2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The NPM2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMNLSSAS STEEKAVTTV LWGCELSQER RTWTFRPQLE GKQSCRLLLH TICLGEKAKE EMHRVEILPP ANQEDKKMQP VTIASLQASV LPMVSMVGVQ LSPPVTFQLR AGSGPVFLSG QERYEASDLT WEEEEEEEGE EEEEEEEDDE DEDADISLEE QSPVKQVKRL VPQKQASVAK KKKLEKEEEE IRASVRDKSP VKKAKATARA KKPGFKK

NPM2 is a member of nucleoplasmin family. NPM2 is a core histones chaperone which takes part in chromatin reprogramming, particularly throughout fertilization and early embryonic development. NPM2 also takes part in sperm DNA decondensation during fertilization.

NPM2 Human Recombinant produced in E. coli is a single polypeptide chain containing 237 amino acids (1-214) and having a molecular mass of 26.6 kDa.NPM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NPM2: Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. Belongs to the nucleoplasmin family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 8p21.3Cellular Component: nuclear chromatin; nucleusMolecular Function: enzyme binding; nucleic acid binding; histone binding; chromatin bindingBiological Process: chromatin remodeling; positive regulation of catalytic activity; embryonic development; positive regulation of meiosis; single fertilization; regulation of exit from mitosis; oocyte differentiation; protein homooligomerization; positive regulation of DNA replication
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q86SE8
NCBI GenInfo Identifier:37537936
NCBI Gene ID:10361
NCBI Accession:Q86SE8.1
UniProt Secondary Accession:Q86SE8,Q6NVH6, B3KSU0, D3DSQ8
UniProt Related Accession:Q86SE8
Molecular Weight:15,238 Da
NCBI Full Name:Nucleoplasmin-2
NCBI Synonym Full Names:nucleophosmin/nucleoplasmin 2
NCBI Official Symbol:NPM2  
NCBI Official Synonym Symbols:
NCBI Protein Information:nucleoplasmin-2
UniProt Protein Name:Nucleoplasmin-2
UniProt Synonym Protein Names:
Protein Family:Nucleoplasmin
UniProt Gene Name:NPM2  
UniProt Entry Name:NPM2_HUMAN
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