Human NOL3 Recombinant Protein (RPPB4116)

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SKU:
RPPB4116
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
NOL3
Synonyms:
Nucleolar protein 3 (apoptosis repressor with CARD domain)
Synonyms:
Muscle-enriched cytoplasmic protein
Synonyms:
Nucleolar protein of 30 kDa
Synonyms:
Apoptosis repressor with CARD
Source:
Escherichia Coli
Uniprot:
O60936
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Description

Product Name:Human NOL3 Recombinant Protein
Product Code:RPPB4116
Size:20µg
Species:Human
Target:NOL3
Synonyms:Nucleolar protein 3 (apoptosis repressor with CARD domain), Muscle-enriched cytoplasmic protein, Nucleolar protein of 30 kDa, Apoptosis repressor with CARD, nucleolar protein 3, NOP30, CARD2, ARC, NOP, MYP, MYC.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The NOL3 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT, 1mM EDTA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGNAQER PSETIDRERK RLVETLQADS GLLLDALLAR GVLTGPEYEA LDALPDAERR VRRLLLLVQG KGEAACQELL RCAQRTAGAP DPAWDWQHVG PGYRDRSYDP PCPGHWTPEA PGSGTTCPGL PRASDPDEAG GPEGSEAVQS GTPEEPEPEL EAEASKEAEP EPEPEPELEP EAEAEPEPEL EPEPDPEPEP DFEERDESED S

Nucleolar protein 3 (NOL3) is primarily expressed in the muscle and is appears in the nucleoplasm and concentrated in nucleoli. NOL3 is an anti-apoptotic protein which down-regulates the enzymatic activities of caspase 2, caspase 8 and tumor protein p53. NOL3 is highly expressed in the heart and skeletal muscle. NOL3 is identified at low levels in the placenta, liver, kidney and pancreas. The NOL3 mRNA and protein levels are stimulated by neuronal activity, which is vital in order to promote neuroplasticity, thus indicating a potential role for NOL3 in activity-dependent changes in dendrite function. NOL3 localizes to the cytoskeleton of neuronal cells and seems to colocalize with F-Actin, though it may connect with an actin-associated protein instead of directly with F-Actin.

NOL3 Human Recombinant produced in E. coli is a single polypeptide chain containing 231 amino acids (1-208) and having a molecular mass of 25.0 kDa.NOL3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Isoform 1: May be involved in RNA splicing.
NCBI Summary:This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Code:O60936
NCBI GenInfo Identifier:20455079
NCBI Gene ID:8996
NCBI Accession:O60936.1
UniProt Secondary Accession:O60936,O60937, B4DFL0,
UniProt Related Accession:O60936
Molecular Weight:29,355 Da
NCBI Full Name:Nucleolar protein 3
NCBI Synonym Full Names:nucleolar protein 3 (apoptosis repressor with CARD domain)
NCBI Official Symbol:NOL3  
NCBI Official Synonym Symbols:ARC; FCM; MYP; NOP; NOP30  
NCBI Protein Information:nucleolar protein 3; nucleolar protein of 30 kDa; muscle-enriched cytoplasmic protein
UniProt Protein Name:Nucleolar protein 3
UniProt Synonym Protein Names:Apoptosis repressor with CARD; Muscle-enriched cytoplasmic protein; Myp; Nucleolar protein of 30 kDa; Nop30
Protein Family:Nucleolar protein
UniProt Gene Name:NOL3  
UniProt Entry Name:NOL3_HUMAN
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