Human NME3 Recombinant Protein (RPPB4108)

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SKU:
RPPB4108
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
NME3
Synonyms:
Protein expressed in non-metastatic cells 3
Synonyms:
DR-nm23
Synonyms:
Nucleoside diphosphate kinase C
Synonyms:
NDPKC
Source:
Escherichia Coli
Uniprot:
Q13232
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Description

Product Name:Human NME3 Recombinant Protein
Product Code:RPPB4108
Size:20µg
Species:Human
Target:NME3
Synonyms:Protein expressed in non-metastatic cells 3, DR-nm23, Nucleoside diphosphate kinase C, NDPKC,  NDK 3, NDP kinase 3, EC 2.7.4.6, NM23H3, KIAA0516, NDPK-C, NM23-H3, c371H6.2, NDP kinase C, nucleoside diphosphate kinase 3, nm23-H3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The NME3 protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 2mM DTT  and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MERTFLAVKP DGVQRRLVGE IVRRFERKGF KLVALKLVQA SEELLREHYA ELRERPFYGR LVKYMASGPV VAMVWQGLDV VRTSRALIGA TNPADAPPGT IRGDFCIEVG KNLIHGSDSV ESARREIALW FRADELLCWE DSAGHWLYE

NME3-a potential suppressor of metastasis, is expressed significantly less in highly metastatic cells than in cells with lower metastatic potential. NME3-a is vital for the synthesis of nucleoside triphosphates and has a part in apoptosis induction and hematopoiesis and is mainly expressed during early stages of myeloid differentiation of highly purified CD34+ cells.

NME3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (22-169.a.a) and having a molecular mass of 19.1kDa. NME3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NME3: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis. Belongs to the NDK family.
UniProt Protein Details:

Protein type:Nucleotide Metabolism - pyrimidine; EC 2.7.4.6; Apoptosis; Nucleotide Metabolism - purine; Kinase, nucleoside diphosphate; Motility/polarity/chemotaxis; Kinase, other; Other group; NDK family

Chromosomal Location of Human Ortholog: 16q13.3

Cellular Component: mitochondrion; cytosol

Molecular Function:metal ion binding; nucleoside diphosphate kinase activity; ATP binding

Biological Process: GTP biosynthetic process; regulation of apoptosis; CTP biosynthetic process; pyrimidine nucleotide metabolic process; apoptosis; UTP biosynthetic process; nucleoside triphosphate biosynthetic process; nucleoside diphosphate phosphorylation; purine nucleotide metabolic process

UniProt Code:Q13232
NCBI GenInfo Identifier:21264477
NCBI Gene ID:4832
NCBI Accession:Q13232.2
UniProt Secondary Accession:Q13232,Q9BWH4,
UniProt Related Accession:Q13232
Molecular Weight:19,015 Da
NCBI Full Name:Nucleoside diphosphate kinase 3
NCBI Synonym Full Names:NME/NM23 nucleoside diphosphate kinase 3
NCBI Official Symbol:NME3  
NCBI Official Synonym Symbols:NDPKC; NDPK-C; NM23H3; DR-nm23; NM23-H3; c371H6.2  
NCBI Protein Information:nucleoside diphosphate kinase 3; NDK 3; NDP kinase 3; NDP kinase C; non-metastatic cells 3, protein expressed in; nucleoside diphosphate kinase C
UniProt Protein Name:Nucleoside diphosphate kinase 3
UniProt Synonym Protein Names:DR-nm23; Nucleoside diphosphate kinase C; NDPKC; nm23-H3
Protein Family:Nucleoside diphosphate kinase
UniProt Gene Name:NME3  
UniProt Entry Name:NDK3_HUMAN
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